Atrial natriuretic factor in normothermic and hypothermic cardiopulmonary bypass

Gianluca Brancaccio, Guido Michielon, Roberto M. Di Donato, Dina Costa, Fabio Falzea, Fabio Miraldi

Research output: Contribution to journalArticlepeer-review


Background: To evaluate the plasmatic changes of atrial natriuretic factor (ANF) during and after cardiopulmonary bypass (CPB) in normothermia and hypothermia. Methods: Twenty-three patients (n=23) undergoing coronary artery bypass graft surgery were randomly assigned to two groups. In Group I (n=11), the patients underwent operation in normothermia; in Group II (n=12), the operation was performed in hypothermia (26°C). Results: Plasma ANF levels were determined after induction of anaesthesia, at the end of CPB and one hour postoperatively. There were no demographic differences between the two groups, diuresis (p=0.90) and natriuresis (p=0.95). Plasma levels of ANF were significantly elevated during and after CPB in both groups (p

Original languageEnglish
Pages (from-to)157-162
Number of pages6
Issue number3
Publication statusPublished - 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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