Abstract
In order to assess the role, if any, of atrial natriuretic peptide (ANP) and hemodynamic changes in diuretic response to concentrated ascitic fluid reinfusion (CAFR) in cirrhotic patients, we studied 10 patients with liver cirrhosis before and after aspiration, concentration and intravenous reinfusion of their ascitic fluid. Basal ANP levels were higher than in normal subjects, but not related to the degree of water and sodium excretion. CAFR induced a variable degree of ANP changes and diuretic response, and these two parameters were strictly correlated to each other. No major changes of cardiac output and systemic vascular resistances were observed after CAFR. In conclusion, the apparent resistance to ANP diuretic action observed in basal condition in cirrhotic patients seems to revert after expanding blood volume by CAFR.
| Original language | English |
|---|---|
| Pages (from-to) | 67-72 |
| Number of pages | 6 |
| Journal | Nephron |
| Volume | 65 |
| Issue number | 1 |
| Publication status | Published - 1993 |
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Keywords
- Ascitic fluid reinfusion
- Atrial natriuretic peptide
- Hepatorenal syndrome
- Liver cirrhosis
ASJC Scopus subject areas
- Nephrology
Cite this
Atrial natriuretic peptide and hemodynamic changes after concentrated ascitic fluid reinfusion in cirrhotic patients. / Messa, P.; Cannella, G.; Mioni, G.; Boscutti, G.; Messa, M.; De Biasi, F.; Cioni, A.
In: Nephron, Vol. 65, No. 1, 1993, p. 67-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Atrial natriuretic peptide and hemodynamic changes after concentrated ascitic fluid reinfusion in cirrhotic patients
AU - Messa, P.
AU - Cannella, G.
AU - Mioni, G.
AU - Boscutti, G.
AU - Messa, M.
AU - De Biasi, F.
AU - Cioni, A.
PY - 1993
Y1 - 1993
N2 - In order to assess the role, if any, of atrial natriuretic peptide (ANP) and hemodynamic changes in diuretic response to concentrated ascitic fluid reinfusion (CAFR) in cirrhotic patients, we studied 10 patients with liver cirrhosis before and after aspiration, concentration and intravenous reinfusion of their ascitic fluid. Basal ANP levels were higher than in normal subjects, but not related to the degree of water and sodium excretion. CAFR induced a variable degree of ANP changes and diuretic response, and these two parameters were strictly correlated to each other. No major changes of cardiac output and systemic vascular resistances were observed after CAFR. In conclusion, the apparent resistance to ANP diuretic action observed in basal condition in cirrhotic patients seems to revert after expanding blood volume by CAFR.
AB - In order to assess the role, if any, of atrial natriuretic peptide (ANP) and hemodynamic changes in diuretic response to concentrated ascitic fluid reinfusion (CAFR) in cirrhotic patients, we studied 10 patients with liver cirrhosis before and after aspiration, concentration and intravenous reinfusion of their ascitic fluid. Basal ANP levels were higher than in normal subjects, but not related to the degree of water and sodium excretion. CAFR induced a variable degree of ANP changes and diuretic response, and these two parameters were strictly correlated to each other. No major changes of cardiac output and systemic vascular resistances were observed after CAFR. In conclusion, the apparent resistance to ANP diuretic action observed in basal condition in cirrhotic patients seems to revert after expanding blood volume by CAFR.
KW - Ascitic fluid reinfusion
KW - Atrial natriuretic peptide
KW - Hepatorenal syndrome
KW - Liver cirrhosis
UR - http://www.scopus.com/inward/record.url?scp=0027304658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027304658&partnerID=8YFLogxK
M3 - Article
C2 - 8413794
AN - SCOPUS:0027304658
VL - 65
SP - 67
EP - 72
JO - Experimental Nephrology
JF - Experimental Nephrology
SN - 0028-2766
IS - 1
ER -