Atrial natriuretic peptide and hemodynamic changes during normal human pregnancy

C. Sala, M. Campise, G. Ambroso, T. Motta, A. Zanchetti, A. Morganti

Research output: Contribution to journalArticlepeer-review


We compared plasma atrial natriuretic peptide (ANP) and cGMP levels during normal pregnancy-a condition characterized by hypervolemia, high cardiac output, and decreased vascular resistance-with postpartum levels and assessed their relation to pregnancy-induced hemodynamic changes. Humoral and hemodynamic variables were measured in healthy women subjects in the supine and upright postures at each trimester of pregnancy and postpartum. Supine plasma ANP was increased throughout pregnancy (32±5, 21±3, and 19±2 versus 15±1 pmol · L -1, respectively, at each trimester versus postpartum), as was cGMP (8.6±1, 7.1±1, and 6.6±1 versus 5.6±1 nmol · L -1), and their increments were directly related (r=.68, P-2), whereas after subjects stood it was always higher (56±3, 58±3, and 49±2 versus 44±2 mL · m -2); thus, stroke volume tended to increase in response to standing in late pregnancy. Supine cardiac index had a similar trend, which was opposite to that of total peripheral resistance (1213±62, 1265±79, and 1729±89 versus 1654±92 dyne · s -1 · cm -5 · m -2). The increments of supine ANP throughout pregnancy were directly related to the changes of stroke volume (r=.40, P

Original languageEnglish
Pages (from-to)631-636
Number of pages6
Issue number4 I
Publication statusPublished - 1995


  • atrial natriuretic peptide
  • blood volume
  • cyclic guanosine 3'-5' monophosphate
  • hemodynamics
  • pregnancy

ASJC Scopus subject areas

  • Internal Medicine


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