Atrial natriuretic peptide in multiple system atrophy

Maurizio Bevilacqua, Guido Norbiato, Velella Righini, Lucia Castelli, Angela Rogolino, Raffaello Furlan, Simona Piazza, Enrica Chebat, Tarcisio Vago

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Central nervous system feedback loops centered on hypothalamic neurons control atrial natriuretic peptide (ANP). We evaluated the ANP response to arterial hypotension, isotonic blood volume expansion, and increase in plasma osmolality in 14 patients with multiple system atrophy (MSA). Seven of the patients were characterized by a lack of vasopressin response to hypotension (MSA type B), suggesting chronic sinoaortic denervation, and seven by a preserved response (MSA type A). Orthostatic hypotension decreased ANP in controls and type A patients, whereas ANP in type B was not affected. Isotonic saline infusion increased ANP and diuresis in controls and type A patients, whereas it did not affect ANP in type B. Osmotic load increased plasma osmolality and vasopressin in controls and MSA patients and ANP in controls and type A but not in type B patients. In MSA patients with altered afferent control of vasopressin, ANP secretion is not stimulated by blood volume expansion, osmotic load, or blood pressure, suggesting that afferent excitatory control plays a role in the release of ANP.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume271
Issue number4 40-4
Publication statusPublished - Oct 1996

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Multiple System Atrophy
Atrial Natriuretic Factor
Vasopressins
Brain Natriuretic Peptide
Blood Volume
Hypotension
Osmolar Concentration
Orthostatic Hypotension
Diuresis
Osmotic Pressure
Denervation
Central Nervous System
Blood Pressure
Neurons

Keywords

  • sinoaortic receptors
  • vasopressin

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Bevilacqua, M., Norbiato, G., Righini, V., Castelli, L., Rogolino, A., Furlan, R., ... Vago, T. (1996). Atrial natriuretic peptide in multiple system atrophy. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 271(4 40-4).

Atrial natriuretic peptide in multiple system atrophy. / Bevilacqua, Maurizio; Norbiato, Guido; Righini, Velella; Castelli, Lucia; Rogolino, Angela; Furlan, Raffaello; Piazza, Simona; Chebat, Enrica; Vago, Tarcisio.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 271, No. 4 40-4, 10.1996.

Research output: Contribution to journalArticle

Bevilacqua, M, Norbiato, G, Righini, V, Castelli, L, Rogolino, A, Furlan, R, Piazza, S, Chebat, E & Vago, T 1996, 'Atrial natriuretic peptide in multiple system atrophy', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 271, no. 4 40-4.
Bevilacqua, Maurizio ; Norbiato, Guido ; Righini, Velella ; Castelli, Lucia ; Rogolino, Angela ; Furlan, Raffaello ; Piazza, Simona ; Chebat, Enrica ; Vago, Tarcisio. / Atrial natriuretic peptide in multiple system atrophy. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1996 ; Vol. 271, No. 4 40-4.
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