To investigate the effects of postural changes and upright exercise on atrial natriuretic peptide release and renin-angiotensin-aldosterone system behavior in patients with venous valvular insufficiency, plasma ANP, plasma renin activity and aldosterone were measured in 11 patients with venous disease and in 11 age-matched controls. In patients with large varicose veins and venous valvular dysfunction, standing was associated with a greater fall in circulating ANP levels (p <0.05) and upright exercise was accompanied by a smaller rise in ANP concentrations (p <0.05) as compared with controls. A significant (p <0.001) inverse relationship was found between the number of venous segments with reflux and both upright and exercise plasma ANP concentrations (r= -0.91; r= -0.84, respectively). In the two groups the response of the renin-angiotensin-aldosterone system to upright position and physical stress was similar. These results suggest that a decreased atrial stretch, due to a reduced venous return, could account for the blunted ANP response to erect posture and exercise in patients with venous valvular incompetency.
|Number of pages||5|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine