Atrioventricular Canal in Down Syndrome: Prevalence of Associated Cardiac Malformations Compared With Patients Without Down Syndrome

Bruno Marino, Ugo Vairo, Antonio Corno, Simonetta Nava, Paolo Guccione, Raffaele Calabró, Carlo Marcelletti

Research output: Contribution to journalArticle

Abstract

The atrioventricular canal is the “classic” congenital heart anomaly in Down syndrome. We may learn more of the nature of this disorder by careful study of the anatomic characteristics of the cardiac lesions and by comparing these lesions in patients with and patients without Down syndrome. We reviewed the clinical characteristics (echocardiographic and angiocardiographic) of 220 patients with atrioventricular canal and compared the prevalence of anatomic types and associated cardiac malformations in children with (105) and without (115) Down syndrome. In patients with Down syndrome, the complete form of atrioventricular canal was prevalent, with a high frequency of associated Fallot's tetralogy. Partial atrioventricular canal and left-sided anomalies were more common in patients without Down syndrome. Down syndrome is associated with a simpler type of atrioventricular canal when compared with patients with a normal chromosome configuration.

Original languageEnglish
Pages (from-to)1120-1122
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume144
Issue number10
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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