AT1R-AT2R Cross Talk

Carmine Savoia, Massimo Volpe

Research output: Chapter in Book/Report/Conference proceedingChapter


In vitro and in vivo studies have shown that angiotensin II type 1 receptor (AT1R) stimulation may regulate the expression of angiotensin II type 2 receptor (AT2R), suggesting the existence of a complex cross regulatory mechanism between the two subtype receptors. In the vasculature, a negative cross talk between AT2R and AT1R may also occur in terms of reduced AT1R expression and signaling in the presence of AT2R stimulation and/or overexpression. Finally, a functional counterregulatory mechanism among angiotensin II (Ang II) subtype receptors and growth-promoting receptors may occur at the expression and signaling level. This might contribute to the modulation of the Ang II-induced damage in the cardiovascular system.

Original languageEnglish
Title of host publicationThe Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications
PublisherElsevier Inc.
Number of pages5
ISBN (Print)9780128014851, 9780128013649
Publication statusPublished - Apr 22 2015


  • Angiotensin II
  • Angiotensin receptors
  • AT<inf>1</inf>R
  • AT<inf>2</inf>R
  • Cross talk mechanism
  • Receptor dimerization
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Medicine(all)

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