AT1R-AT2R Cross Talk

Carmine Savoia, Massimo Volpe

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

In vitro and in vivo studies have shown that angiotensin II type 1 receptor (AT1R) stimulation may regulate the expression of angiotensin II type 2 receptor (AT2R), suggesting the existence of a complex cross regulatory mechanism between the two subtype receptors. In the vasculature, a negative cross talk between AT2R and AT1R may also occur in terms of reduced AT1R expression and signaling in the presence of AT2R stimulation and/or overexpression. Finally, a functional counterregulatory mechanism among angiotensin II (Ang II) subtype receptors and growth-promoting receptors may occur at the expression and signaling level. This might contribute to the modulation of the Ang II-induced damage in the cardiovascular system.

Original languageEnglish
Title of host publicationThe Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications
PublisherElsevier Inc.
Pages35-39
Number of pages5
ISBN (Print)9780128014851, 9780128013649
DOIs
Publication statusPublished - Apr 22 2015

Fingerprint

Receptor Cross-Talk
Angiotensin Type 2 Receptor
Angiotensin Type 1 Receptor
Angiotensin Receptors
Cardiovascular System
Angiotensin II
Growth

Keywords

  • Angiotensin II
  • Angiotensin receptors
  • AT<inf>1</inf>R
  • AT<inf>2</inf>R
  • Cross talk mechanism
  • Receptor dimerization
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Savoia, C., & Volpe, M. (2015). AT1R-AT2R Cross Talk. In The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications (pp. 35-39). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801364-9.00005-5

AT1R-AT2R Cross Talk. / Savoia, Carmine; Volpe, Massimo.

The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. Elsevier Inc., 2015. p. 35-39.

Research output: Chapter in Book/Report/Conference proceedingChapter

Savoia, C & Volpe, M 2015, AT1R-AT2R Cross Talk. in The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. Elsevier Inc., pp. 35-39. https://doi.org/10.1016/B978-0-12-801364-9.00005-5
Savoia C, Volpe M. AT1R-AT2R Cross Talk. In The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. Elsevier Inc. 2015. p. 35-39 https://doi.org/10.1016/B978-0-12-801364-9.00005-5
Savoia, Carmine ; Volpe, Massimo. / AT1R-AT2R Cross Talk. The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. Elsevier Inc., 2015. pp. 35-39
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