Próba oceny ryzyka nawrotu złośliwej arytmii komorowej na podstawie prostych nieinwazyjnych badań diagnostycznych

Translated title of the contribution: Attempt to assess the risk of recurrence of life-threatening ventricular arrhythmia using simple non-invasive tests

Ludmiła Daniłowicz-Szymanowicz, Grzegorz Raczak, Gian Domenico Pinna, Roberto Maestri, Małgorzata Szwoch, Andrzej Lubiński, Jacek Kubica, Grazyna Świa̧tecka

Research output: Contribution to journalArticle

Abstract

Baroreflex sensitivity (BRS), as assessed using phenylephrine method, and depressed 24- hour heart rate variability (HRV) have been shown to be powerful predictors of life- threatening ventricular arrhythmias. However, before these tests are widely used, their methodology has to be simplified. The aim of this study was to assess the prognostic value of simple non- invasive BRS parameter (Robbe index, BRS-RI) and short- term HRV, together with left ventricular ejection fraction (LVEF) and late potentials (LP) assessment in patients after myocardial infarction (MI) with documented history of ventricular tachycardia (VT) and ventricular fibrillation (VF). Material and methods. The observation was conducted on 53 patients after MI with documented VT or VF. . They were was devided into two group: with or without reccurence arrhythmia. During the follow- up malignant ventricular arrhythmia events occurred in 31 patients VT/VF(+), no VT or VF was recorded in the 22 subjects VT/VF(-). In all patients the following parameters were analyzed: BRS-RI (transfer function, 0.07-0.14 Hz), HRV parameters such as: SDNN, rMSSD, pNN50, LF, LF (NU), LF/HF. Additionally, LVEF and LP were assessed. Results. In the VT/VF(+) and VT/VF(-) groups, values of analyzed parameters were: BRS-RI: 4.4 ± 2.5 and 8.4 ± 6.1 ms/mm Hg (p=0.03); BRS-RI≤3 ms/mm Hg: 8/15 and 2/16 (p=0.02); SDNN: 23.0 ± 18.0 and 20.0 ± 11.6 ms (p=0.99); rMSSD: 70.9 ± 69.8 and 34.1 ± 30.2 ms (p=0.34); pNN50: 10.7 ± 14.6 and 4.4 ± 9.0% (p=0.7); LF: 204.5 ± 509.7 and 160.7 ± 265.8 ms 2 (p=0.95); LF (NU): 0.5+0.4 and 0.5 ± 0.3 (NU) (p=0.77); LF/HF: 1.3 ± 1.2 and 2.1 ± 2.2 (p=0.49); LVEF: 32.5 ± 9.1 and 39.8 ± 13.3% (p= 0.03); LP: 19/24 and 15/19 (p= 0.99). The only indices of prognostic values were Robbe- index and LVEF. Their prognostic value in prediction of arrhythmic event occurrence was independent of each other's and of age, time elapsed from MI and number of MI (p= 0,007). Non- diagnostic values of BRS-RI were found in 22 chorych (42%). Conclusions. Among the evaluated indices, only LVEF and Robbe- index have prognostic value in prediction of life- threatening ventricular arrhythmia reccurrence after myocardial infarction. However, a high percentage of non-diagnostic values obtained in BRS-RI assessment limits the usefulness of this index.

Original languagePolish
Pages (from-to)558-563
Number of pages6
JournalPolski Merkuriusz Lekarski
Volume17
Issue number102
Publication statusPublished - 2004

Fingerprint

Baroreflex
Ventricular Fibrillation
Ventricular Tachycardia
Cardiac Arrhythmias
Recurrence
Stroke Volume
Myocardial Infarction
Heart Rate
Phenylephrine
Observation

Keywords

  • Baroreflex sensitivity
  • Heart rate variability
  • Ventricular fibrillation
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Daniłowicz-Szymanowicz, L., Raczak, G., Pinna, G. D., Maestri, R., Szwoch, M., Lubiński, A., ... Świa̧tecka, G. (2004). Próba oceny ryzyka nawrotu złośliwej arytmii komorowej na podstawie prostych nieinwazyjnych badań diagnostycznych. Polski Merkuriusz Lekarski, 17(102), 558-563.

Próba oceny ryzyka nawrotu złośliwej arytmii komorowej na podstawie prostych nieinwazyjnych badań diagnostycznych. / Daniłowicz-Szymanowicz, Ludmiła; Raczak, Grzegorz; Pinna, Gian Domenico; Maestri, Roberto; Szwoch, Małgorzata; Lubiński, Andrzej; Kubica, Jacek; Świa̧tecka, Grazyna.

In: Polski Merkuriusz Lekarski, Vol. 17, No. 102, 2004, p. 558-563.

Research output: Contribution to journalArticle

Daniłowicz-Szymanowicz, L, Raczak, G, Pinna, GD, Maestri, R, Szwoch, M, Lubiński, A, Kubica, J & Świa̧tecka, G 2004, 'Próba oceny ryzyka nawrotu złośliwej arytmii komorowej na podstawie prostych nieinwazyjnych badań diagnostycznych', Polski Merkuriusz Lekarski, vol. 17, no. 102, pp. 558-563.
Daniłowicz-Szymanowicz, Ludmiła ; Raczak, Grzegorz ; Pinna, Gian Domenico ; Maestri, Roberto ; Szwoch, Małgorzata ; Lubiński, Andrzej ; Kubica, Jacek ; Świa̧tecka, Grazyna. / Próba oceny ryzyka nawrotu złośliwej arytmii komorowej na podstawie prostych nieinwazyjnych badań diagnostycznych. In: Polski Merkuriusz Lekarski. 2004 ; Vol. 17, No. 102. pp. 558-563.
@article{6475ae4e86db4b6db73f753851c85d8b,
title = "Pr{\'o}ba oceny ryzyka nawrotu złośliwej arytmii komorowej na podstawie prostych nieinwazyjnych badań diagnostycznych",
abstract = "Baroreflex sensitivity (BRS), as assessed using phenylephrine method, and depressed 24- hour heart rate variability (HRV) have been shown to be powerful predictors of life- threatening ventricular arrhythmias. However, before these tests are widely used, their methodology has to be simplified. The aim of this study was to assess the prognostic value of simple non- invasive BRS parameter (Robbe index, BRS-RI) and short- term HRV, together with left ventricular ejection fraction (LVEF) and late potentials (LP) assessment in patients after myocardial infarction (MI) with documented history of ventricular tachycardia (VT) and ventricular fibrillation (VF). Material and methods. The observation was conducted on 53 patients after MI with documented VT or VF. . They were was devided into two group: with or without reccurence arrhythmia. During the follow- up malignant ventricular arrhythmia events occurred in 31 patients VT/VF(+), no VT or VF was recorded in the 22 subjects VT/VF(-). In all patients the following parameters were analyzed: BRS-RI (transfer function, 0.07-0.14 Hz), HRV parameters such as: SDNN, rMSSD, pNN50, LF, LF (NU), LF/HF. Additionally, LVEF and LP were assessed. Results. In the VT/VF(+) and VT/VF(-) groups, values of analyzed parameters were: BRS-RI: 4.4 ± 2.5 and 8.4 ± 6.1 ms/mm Hg (p=0.03); BRS-RI≤3 ms/mm Hg: 8/15 and 2/16 (p=0.02); SDNN: 23.0 ± 18.0 and 20.0 ± 11.6 ms (p=0.99); rMSSD: 70.9 ± 69.8 and 34.1 ± 30.2 ms (p=0.34); pNN50: 10.7 ± 14.6 and 4.4 ± 9.0{\%} (p=0.7); LF: 204.5 ± 509.7 and 160.7 ± 265.8 ms 2 (p=0.95); LF (NU): 0.5+0.4 and 0.5 ± 0.3 (NU) (p=0.77); LF/HF: 1.3 ± 1.2 and 2.1 ± 2.2 (p=0.49); LVEF: 32.5 ± 9.1 and 39.8 ± 13.3{\%} (p= 0.03); LP: 19/24 and 15/19 (p= 0.99). The only indices of prognostic values were Robbe- index and LVEF. Their prognostic value in prediction of arrhythmic event occurrence was independent of each other's and of age, time elapsed from MI and number of MI (p= 0,007). Non- diagnostic values of BRS-RI were found in 22 chorych (42{\%}). Conclusions. Among the evaluated indices, only LVEF and Robbe- index have prognostic value in prediction of life- threatening ventricular arrhythmia reccurrence after myocardial infarction. However, a high percentage of non-diagnostic values obtained in BRS-RI assessment limits the usefulness of this index.",
keywords = "Baroreflex sensitivity, Heart rate variability, Ventricular fibrillation, Ventricular tachycardia",
author = "Ludmiła Daniłowicz-Szymanowicz and Grzegorz Raczak and Pinna, {Gian Domenico} and Roberto Maestri and Małgorzata Szwoch and Andrzej Lubiński and Jacek Kubica and Grazyna Świa̧tecka",
year = "2004",
language = "Polish",
volume = "17",
pages = "558--563",
journal = "Polski Merkuriusz Lekarski",
issn = "1426-9686",
publisher = "MedPress",
number = "102",

}

TY - JOUR

T1 - Próba oceny ryzyka nawrotu złośliwej arytmii komorowej na podstawie prostych nieinwazyjnych badań diagnostycznych

AU - Daniłowicz-Szymanowicz, Ludmiła

AU - Raczak, Grzegorz

AU - Pinna, Gian Domenico

AU - Maestri, Roberto

AU - Szwoch, Małgorzata

AU - Lubiński, Andrzej

AU - Kubica, Jacek

AU - Świa̧tecka, Grazyna

PY - 2004

Y1 - 2004

N2 - Baroreflex sensitivity (BRS), as assessed using phenylephrine method, and depressed 24- hour heart rate variability (HRV) have been shown to be powerful predictors of life- threatening ventricular arrhythmias. However, before these tests are widely used, their methodology has to be simplified. The aim of this study was to assess the prognostic value of simple non- invasive BRS parameter (Robbe index, BRS-RI) and short- term HRV, together with left ventricular ejection fraction (LVEF) and late potentials (LP) assessment in patients after myocardial infarction (MI) with documented history of ventricular tachycardia (VT) and ventricular fibrillation (VF). Material and methods. The observation was conducted on 53 patients after MI with documented VT or VF. . They were was devided into two group: with or without reccurence arrhythmia. During the follow- up malignant ventricular arrhythmia events occurred in 31 patients VT/VF(+), no VT or VF was recorded in the 22 subjects VT/VF(-). In all patients the following parameters were analyzed: BRS-RI (transfer function, 0.07-0.14 Hz), HRV parameters such as: SDNN, rMSSD, pNN50, LF, LF (NU), LF/HF. Additionally, LVEF and LP were assessed. Results. In the VT/VF(+) and VT/VF(-) groups, values of analyzed parameters were: BRS-RI: 4.4 ± 2.5 and 8.4 ± 6.1 ms/mm Hg (p=0.03); BRS-RI≤3 ms/mm Hg: 8/15 and 2/16 (p=0.02); SDNN: 23.0 ± 18.0 and 20.0 ± 11.6 ms (p=0.99); rMSSD: 70.9 ± 69.8 and 34.1 ± 30.2 ms (p=0.34); pNN50: 10.7 ± 14.6 and 4.4 ± 9.0% (p=0.7); LF: 204.5 ± 509.7 and 160.7 ± 265.8 ms 2 (p=0.95); LF (NU): 0.5+0.4 and 0.5 ± 0.3 (NU) (p=0.77); LF/HF: 1.3 ± 1.2 and 2.1 ± 2.2 (p=0.49); LVEF: 32.5 ± 9.1 and 39.8 ± 13.3% (p= 0.03); LP: 19/24 and 15/19 (p= 0.99). The only indices of prognostic values were Robbe- index and LVEF. Their prognostic value in prediction of arrhythmic event occurrence was independent of each other's and of age, time elapsed from MI and number of MI (p= 0,007). Non- diagnostic values of BRS-RI were found in 22 chorych (42%). Conclusions. Among the evaluated indices, only LVEF and Robbe- index have prognostic value in prediction of life- threatening ventricular arrhythmia reccurrence after myocardial infarction. However, a high percentage of non-diagnostic values obtained in BRS-RI assessment limits the usefulness of this index.

AB - Baroreflex sensitivity (BRS), as assessed using phenylephrine method, and depressed 24- hour heart rate variability (HRV) have been shown to be powerful predictors of life- threatening ventricular arrhythmias. However, before these tests are widely used, their methodology has to be simplified. The aim of this study was to assess the prognostic value of simple non- invasive BRS parameter (Robbe index, BRS-RI) and short- term HRV, together with left ventricular ejection fraction (LVEF) and late potentials (LP) assessment in patients after myocardial infarction (MI) with documented history of ventricular tachycardia (VT) and ventricular fibrillation (VF). Material and methods. The observation was conducted on 53 patients after MI with documented VT or VF. . They were was devided into two group: with or without reccurence arrhythmia. During the follow- up malignant ventricular arrhythmia events occurred in 31 patients VT/VF(+), no VT or VF was recorded in the 22 subjects VT/VF(-). In all patients the following parameters were analyzed: BRS-RI (transfer function, 0.07-0.14 Hz), HRV parameters such as: SDNN, rMSSD, pNN50, LF, LF (NU), LF/HF. Additionally, LVEF and LP were assessed. Results. In the VT/VF(+) and VT/VF(-) groups, values of analyzed parameters were: BRS-RI: 4.4 ± 2.5 and 8.4 ± 6.1 ms/mm Hg (p=0.03); BRS-RI≤3 ms/mm Hg: 8/15 and 2/16 (p=0.02); SDNN: 23.0 ± 18.0 and 20.0 ± 11.6 ms (p=0.99); rMSSD: 70.9 ± 69.8 and 34.1 ± 30.2 ms (p=0.34); pNN50: 10.7 ± 14.6 and 4.4 ± 9.0% (p=0.7); LF: 204.5 ± 509.7 and 160.7 ± 265.8 ms 2 (p=0.95); LF (NU): 0.5+0.4 and 0.5 ± 0.3 (NU) (p=0.77); LF/HF: 1.3 ± 1.2 and 2.1 ± 2.2 (p=0.49); LVEF: 32.5 ± 9.1 and 39.8 ± 13.3% (p= 0.03); LP: 19/24 and 15/19 (p= 0.99). The only indices of prognostic values were Robbe- index and LVEF. Their prognostic value in prediction of arrhythmic event occurrence was independent of each other's and of age, time elapsed from MI and number of MI (p= 0,007). Non- diagnostic values of BRS-RI were found in 22 chorych (42%). Conclusions. Among the evaluated indices, only LVEF and Robbe- index have prognostic value in prediction of life- threatening ventricular arrhythmia reccurrence after myocardial infarction. However, a high percentage of non-diagnostic values obtained in BRS-RI assessment limits the usefulness of this index.

KW - Baroreflex sensitivity

KW - Heart rate variability

KW - Ventricular fibrillation

KW - Ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=11844294009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11844294009&partnerID=8YFLogxK

M3 - Articolo

C2 - 15771121

AN - SCOPUS:11844294009

VL - 17

SP - 558

EP - 563

JO - Polski Merkuriusz Lekarski

JF - Polski Merkuriusz Lekarski

SN - 1426-9686

IS - 102

ER -