Attention-deficit hyperactivity disorder (ADHD) and tuberous sclerosis complex

Elisa D'Agati, Romina Moavero, Caterina Cerminara, Paolo Curatolo

Research output: Contribution to journalArticlepeer-review

Abstract

The neurobiological basis of attention-deficit hyperactivity disorder (ADHD) in tuberous sclerosis complex is still largely unknown. Cortical tubers may disrupt several brain networks that control different types of attention. Frontal lobe dysfunction due to seizures or epileptiform electroencephalographic discharges may perturb the development of brain systems that underpin attentional and hyperactive functions during a critical early stage of brain maturation. Comorbidity of attention-deficit hyperactivity disorder (ADHD) with mental retardation and autism spectrum disorders is frequent in children with tuberous sclerosis. Attention-deficit

Original languageEnglish
Pages (from-to)1282-1287
Number of pages6
JournalJournal of Child Neurology
Volume24
Issue number10
DOIs
Publication statusPublished - 2009

Keywords

  • ADHD
  • Antiepileptic drugs
  • Autism
  • Methylphenidate
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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