Attention-deficit hyperactivity disorder (ADHD) and tuberous sclerosis complex

Elisa D'Agati, Romina Moavero, Caterina Cerminara, Paolo Curatolo

Research output: Contribution to journalArticlepeer-review


The neurobiological basis of attention-deficit hyperactivity disorder (ADHD) in tuberous sclerosis complex is still largely unknown. Cortical tubers may disrupt several brain networks that control different types of attention. Frontal lobe dysfunction due to seizures or epileptiform electroencephalographic discharges may perturb the development of brain systems that underpin attentional and hyperactive functions during a critical early stage of brain maturation. Comorbidity of attention-deficit hyperactivity disorder (ADHD) with mental retardation and autism spectrum disorders is frequent in children with tuberous sclerosis. Attention-deficit

Original languageEnglish
Pages (from-to)1282-1287
Number of pages6
JournalJournal of Child Neurology
Issue number10
Publication statusPublished - 2009


  • ADHD
  • Antiepileptic drugs
  • Autism
  • Methylphenidate
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Attention-deficit hyperactivity disorder (ADHD) and tuberous sclerosis complex'. Together they form a unique fingerprint.

Cite this