Attention-deficit/hyperactivity disorder, joint hypermobility-related disorders and pain: expanding body-mind connections to the developmental age

Carolina Baeza-Velasco, Lorenzo Sinibaldi, Marco Castori

Research output: Contribution to journalReview article

Abstract

Attention-deficit/hyperactivity disorder (ADHD) and generalized joint hypermobility (JH) are two separated conditions, assessed, and managed by different specialists without overlapping interests. Recently, some researchers highlighted an unexpected association between these two clinical entities. This happens in a scenario of increasing awareness on the protean detrimental effects that congenital anomalies of the connective tissue may have on human health and development. To review pertinent literature to identify possible connections between ADHD and GJH, special emphasis was put on musculoskeletal pain and syndromic presentations of GJH, particularly the hypermobile Ehlers–Danlos syndrome. A comprehensive search of scientific databases and references lists was conducted, encompassing publications based on qualitative and quantitative research. Impaired coordination and proprioception, fatigue, chronic pain, and dysautonomia are identified as potential bridges between ADHD and JH. Based on these findings, a map of the pathophysiological and psychopathological pathways connecting both conditions is proposed. Although ADHD and JH are traditionally separated human attributes, their association may testify for the dyadic nature of mind-body connections during critical periods of post-natal development. Such a mixed picture has potentially important consequences in terms of disability and deserves more clinical and research attention.

Original languageEnglish
Pages (from-to)163-175
Number of pages13
JournalADHD Attention Deficit and Hyperactivity Disorders
Volume10
Issue number3
DOIs
Publication statusPublished - Sep 1 2018

Keywords

  • Attention-deficit/hyperactivity disorder
  • Connective tissue
  • Developmental coordination disorder
  • Ehlers–Danlos syndrome
  • Fibromyalgia
  • Joint hypermobility
  • Pain

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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