Attention influences the excitability of cortical motor areas in healthy humans

Antonella Conte, Francesca Gilio, Ennio Iezzi, Vittorio Frasca, Maurizio Inghilleri, Alfredo Berardelli

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

We investigated whether human attentional processes influence the size of the motor evoked potentials (MEP) facilitation and the duration of the cortical silent period (CSP) elicited by high-frequency repetitive transcranial magnetic stimulation (rTMS). In healthy subjects we assessed the effects of 5 Hz-rTMS, delivered in trains of 10 stimuli at suprathreshold intensity over the hand motor area, on the MEP size and CSP duration in different attention-demanding conditions: "relaxed," "target hand," and "non-target hand" condition. We also investigated the inhibitory effects of 1 Hz-rTMS conditioning to the premotor cortex on the 5 Hz-rTMS induced MEP facilitation. F-waves evoked by ulnar nerve stimulation were also recorded. rTMS trains elicited a larger MEP size facilitation when the subjects looked at the target hand whereas the increase in CSP duration during rTMS remained unchanged during the three attention-demanding conditions. The conditioning inhibitory stimulation delivered to the premotor cortex decreased the MEP facilitation during the "target hand" condition, leaving the MEP facilitation during the other conditions unchanged. None of the attentional conditions elicited changes in the F wave. In healthy subjects attentional processes influence the size of the MEP facilitation elicited by high-frequency rTMS and do so through premotor-to-motor connections.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalExperimental Brain Research
Volume182
Issue number1
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Motor Evoked Potentials
Transcranial Magnetic Stimulation
Motor Cortex
Hand
Healthy Volunteers
Ulnar Nerve
Cortical Excitability

Keywords

  • Attention
  • Cortical plasticity
  • Healthy subjects
  • Magnetic stimulation
  • Motor cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Attention influences the excitability of cortical motor areas in healthy humans. / Conte, Antonella; Gilio, Francesca; Iezzi, Ennio; Frasca, Vittorio; Inghilleri, Maurizio; Berardelli, Alfredo.

In: Experimental Brain Research, Vol. 182, No. 1, 09.2007, p. 109-117.

Research output: Contribution to journalArticle

Conte, Antonella ; Gilio, Francesca ; Iezzi, Ennio ; Frasca, Vittorio ; Inghilleri, Maurizio ; Berardelli, Alfredo. / Attention influences the excitability of cortical motor areas in healthy humans. In: Experimental Brain Research. 2007 ; Vol. 182, No. 1. pp. 109-117.
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