Attention modulation regulates both motor and non-motor performance: A high-density EEG study in Parkinson's disease

B. Perfetti, C. Moisello, S. Lanzafame, S. Varanese, E. C. Landsness, M. Onofrj, A. Di Rocco, G. Tononi, M. F. Ghilardi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We have previously shown that, in early stages of Parkinson's disease (PD), patients with higher reaction times are also more impaired in visual sequence learning, suggesting that movement preparation shares resources with the learning of visuospatial sequences. Here, we ascertained whether, in patients with PD, the pattern of the neural correlates of attentional processes of movement planning predict sequence learning and working memory abilities. High density Electroencephalography (EEG, 256 electrodes) was recorded in 19 patients with PD performing reaching movements in a choice reaction time paradigm. Patients were also tested with Digit Span and performed a visuomotor sequence learning task that has an important declarative learning component. We found that attenuation of alpha/beta oscillatory activity before the stimulus presentation in frontoparietal regions significantly correlated with reaction time in the choice reaction time task, similarly to what we had previously found in normal subjects. In addition, such activity significantly predicted the declarative indices of sequence learning and the scores in the Digit Span task. These findings suggest that some motor and non motor PD signs might have common neural bases, and thus, might have a similar response to the same behavioral therapy. In addition, these results might help in designing and testing the efficacy of novel rehabilitative approaches to improve specific aspects of motor performance in PD and other neurological disorders.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalArchives Italiennes de Biologie
Volume148
Issue number3
Publication statusPublished - 2010

Fingerprint

Parkinson Disease
Electroencephalography
Learning
Reaction Time
Aptitude
Nervous System Diseases
Short-Term Memory
Electrodes

Keywords

  • Choice reaction time
  • Event related spectral perturbation
  • Reaching
  • Sequence learning
  • Working memory

ASJC Scopus subject areas

  • Medicine(all)
  • Cell Biology
  • Physiology

Cite this

Perfetti, B., Moisello, C., Lanzafame, S., Varanese, S., Landsness, E. C., Onofrj, M., ... Ghilardi, M. F. (2010). Attention modulation regulates both motor and non-motor performance: A high-density EEG study in Parkinson's disease. Archives Italiennes de Biologie, 148(3), 279-288.

Attention modulation regulates both motor and non-motor performance : A high-density EEG study in Parkinson's disease. / Perfetti, B.; Moisello, C.; Lanzafame, S.; Varanese, S.; Landsness, E. C.; Onofrj, M.; Di Rocco, A.; Tononi, G.; Ghilardi, M. F.

In: Archives Italiennes de Biologie, Vol. 148, No. 3, 2010, p. 279-288.

Research output: Contribution to journalArticle

Perfetti, B, Moisello, C, Lanzafame, S, Varanese, S, Landsness, EC, Onofrj, M, Di Rocco, A, Tononi, G & Ghilardi, MF 2010, 'Attention modulation regulates both motor and non-motor performance: A high-density EEG study in Parkinson's disease', Archives Italiennes de Biologie, vol. 148, no. 3, pp. 279-288.
Perfetti B, Moisello C, Lanzafame S, Varanese S, Landsness EC, Onofrj M et al. Attention modulation regulates both motor and non-motor performance: A high-density EEG study in Parkinson's disease. Archives Italiennes de Biologie. 2010;148(3):279-288.
Perfetti, B. ; Moisello, C. ; Lanzafame, S. ; Varanese, S. ; Landsness, E. C. ; Onofrj, M. ; Di Rocco, A. ; Tononi, G. ; Ghilardi, M. F. / Attention modulation regulates both motor and non-motor performance : A high-density EEG study in Parkinson's disease. In: Archives Italiennes de Biologie. 2010 ; Vol. 148, No. 3. pp. 279-288.
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