Attenuation of cholinergic analgesia by nifedipine

Flaminia Pavone, Mario Battaglia, Mario Sansone

Research output: Contribution to journalArticlepeer-review


Nociception was tested in mice receiving oxotremorine or physostigmine either after the dihydropyridine calcium channel blocker nifedipine or the non-calcium antagonist vasodilator hydralazine. Nifedipine did not change the reaction time to thermal stimulation (tail-flick test), but attenuated the prolonging action on tail-flick latencies exerted by the two cholinomimetic agents. Hydralazine had no effect alone nor modified the action of cholinomimetics. The results suggest that attenuation of cholinergic analgesia by nifedipine might be related to not yet defined neuronal changes produced by calcium channel blockade, but changes in the pharmacokinetics of oxotremorine and physostigmine cannot be ruled out.

Original languageEnglish
Pages (from-to)308-310
Number of pages3
JournalBrain Research
Issue number2
Publication statusPublished - Oct 1 1993


  • Mouse
  • Nifedipine
  • Nociception
  • Oxotremorine
  • Physostigmine

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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