Attenuation of leukocyte β2-integrin expression by antithrombin-III

D. Gritti, A. Malinverno, C. Gasparetto, C. J. Wiedermann, Giovanni Ricevuti

Research output: Contribution to journalArticlepeer-review

Abstract

Antithrombin-III exerts antiinflammatory effects via ligation of heparan sulfate proteoglycans. Here we show in vitro that recombinant human antithrombin-III attenuates CD11b/CD18 expression of activated neutrophils and monocytes in whole blood ex vivo. As leukocyte integrin expression is triggered by extracorporeal circulation, this observation may be of relevance for pharmacological treatment during cardiopulmonary bypass.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume17
Issue number1
Publication statusPublished - Jan 2004

Keywords

  • Cardiopulmonary bypass
  • Coagulation
  • Inflammation
  • Leukocytes

ASJC Scopus subject areas

  • Pharmacology

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