Attenuation of the 'white-coat effect' by antihypertensive treatment and regression of target organ damage

Gianfranco Parati, Luisa Ulian, Lorena Sampieri, Paolo Palatini, Alessandra Villani, Alessandro Vanasia, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


This study assessed whether 2 common surrogate measures of the 'white- coat effect,' namely the clinic-daytime and the clinic-home differences in blood pressure (BP), were attenuated by long-term antihypertensive treatment and whether this attenuation is relevant to the treatment-induced regression of left ventricular hypertrophy, thus having clinical significance. We considered data from 206 patients with essential hypertension (aged 20 to 65 years) who had a diastolic BP between 95 and 115 mm Hg and echocardiographic evidence of left ventricular hypertrophy. In each patient, clinic BP, 24-hour ambulatory BP, and left ventricular mass index were assessed at baseline, after 3 and 12 months of treatment with an angiotensin-converting enzyme inhibitor, and after a final 4-week placebo run-off period. At baseline, the clinic-daytime differences in systolic and diastolic BP were 12.1±15.4 and 6.8±10.1 mm Hg, respectively; the corresponding values for the clinic-home differences were 5.7±10.6 and 2.9±6.1 mm Hg, respectively. These differences were reduced by 57.6% and 77.1% (P

Original languageEnglish
Pages (from-to)614-620
Number of pages7
Issue number2
Publication statusPublished - Feb 2000


  • Antihypertensive agents
  • Blood pressure
  • Hypertension, white-coat

ASJC Scopus subject areas

  • Internal Medicine


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