Attitudes of children with leukemia toward repeated deep sedations with propofol

Egidio Barbi, Laura Badina, Federico Marchetti, Roberta Vecchi, Isabella Giuseppin, Irene Bruno, Giulio Zanazzo, Armando Sarti, Alessando Ventura

Research output: Contribution to journalArticlepeer-review


Procedural sedation is generally recommended for children requiring repeated painful diagnostic or therapeutic procedures. A child with leukemia undergoes an average of 20 procedures such as lumbar puncture and bone marrow aspiration through the course of illness. No data are currently available about the psychological impact of repeated sedations on children. The objective of this study was to evaluate the attitudes of patients with leukemia toward repeated deep sedations using propofol. A questionnaire addressing sedation-related distress was given to 30 children with leukemia. Procedure-related distress was evaluated using the Amended Observational Scale of Behavioural Distress. Another questionnaire concerning the same issues was given to an historical group of 39 children who had undergone painful procedures without sedation in previous years. Fear and distress were significantly reduced in the sedation group compared with the historical one. Fear of sedation was reported by 17% of children of this group. Distressed behavior was observed in 27%. In conclusion, sedation-related distress was observed in a subgroup of patients; in these cases, specific strategies could be considered to reduce sedation-related distress.

Original languageEnglish
Pages (from-to)639-643
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Issue number12
Publication statusPublished - Dec 2005


  • Leukemia
  • Patient attitudes
  • Procedural sedation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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