Attualità sulla patogenesi della sclerosi laterale amiotrofica

A. Scontrini, F. E. Pontieri

Research output: Contribution to journalArticle

Abstract

Amyotrophic lateral sclerosis is a neurodegenerative disorder characterized by loss of motor neurons. Here we review the most recent findings related to the pathogenesis of the disease, with emphasis on genetic studies and mechanisms of neurotoxicity by free radicals and excitatory amino acids. The results of these studies provide relevant basis for therapeutics trials with neuroprotective drugs that have been shown to slow the progression of the disease.

Original languageItalian
Pages (from-to)49-54
Number of pages6
JournalGiornale di Neuropsicofarmacologia
Volume22
Issue number2
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmaceutical Science
  • Pharmacology
  • Neuropsychology and Physiological Psychology

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