Atypical aHUS: State of the art

Carla M. Nester; Thomas Barbour; Santiago Rodriquez de Cordoba; Marie Agnes Dragon-Durey; Veronique Fremeaux-Bacchi; Tim H J Goodship; David Kavanagh; Marina Noris; Matthew Pickering; Pilar Sanchez-Corral; Christine Skerka; Peter Zipfel; Richard J H Smith

doi:10.1016/j.molimm.2015.03.246

Atypical aHUS: State of the art

Carla M. Nester, Thomas Barbour, Santiago Rodriquez de Cordoba, Marie Agnes Dragon-Durey, Veronique Fremeaux-Bacchi, Tim H J Goodship, David Kavanagh, Marina Noris, Matthew Pickering, Pilar Sanchez-Corral, Christine Skerka, Peter Zipfel, Richard J H Smith

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Tremendous advances in our understanding of the thrombotic microangiopathies (TMAs) have revealed distinct disease mechanisms within this heterogeneous group of diseases. As a direct result of this knowledge, both children and adults with complement-mediated TMA now enjoy higher expectations for long-term health. In this update on atypical hemolytic uremic syndrome, we review the clinical characteristics; the genetic and acquired drivers of disease; the broad spectrum of environmental triggers; and current diagnosis and treatment options. Many questions remain to be addressed if additional improvements in patient care and outcome are to be achieved in the coming decade.

Original language	English
Pages (from-to)	31-42
Number of pages	12
Journal	Molecular Immunology
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/j.molimm.2015.03.246
Publication status	Published - Sep 1 2015

ASJC Scopus subject areas

Molecular Biology
Immunology
Medicine(all)

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Atypical aHUS : State of the art. / Nester, Carla M.; Barbour, Thomas; de Cordoba, Santiago Rodriquez; Dragon-Durey, Marie Agnes; Fremeaux-Bacchi, Veronique; Goodship, Tim H J; Kavanagh, David; Noris, Marina; Pickering, Matthew; Sanchez-Corral, Pilar; Skerka, Christine; Zipfel, Peter; Smith, Richard J H.

In: Molecular Immunology, Vol. 67, No. 1, 01.09.2015, p. 31-42.

Research output: Contribution to journal › Article › peer-review

Nester, Carla M. ; Barbour, Thomas ; de Cordoba, Santiago Rodriquez ; Dragon-Durey, Marie Agnes ; Fremeaux-Bacchi, Veronique ; Goodship, Tim H J ; Kavanagh, David ; Noris, Marina ; Pickering, Matthew ; Sanchez-Corral, Pilar ; Skerka, Christine ; Zipfel, Peter ; Smith, Richard J H. / Atypical aHUS : State of the art. In: Molecular Immunology. 2015 ; Vol. 67, No. 1. pp. 31-42.

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