Atypical chemokine receptors

From silence to sound

Cinzia Cancellieri, Alessandro Vacchini, Massimo Locati, Raffaella Bonecchi, Elena M. Borroni

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

ACRs (atypical chemokine receptors) were initially referred to as 'silent' receptors on the basis of a lack of signalling and functional activities that are typically observed with conventional chemokine receptors. Although ACRs do not directly induce cell migration, they indirectly control leucocyte recruitment by shaping chemokine gradients in tissues through degradation, transcytosis or local concentration of their cognate ligands. Recent evidence also suggests that these biological activities are supported by G-proteinindependent, β-arrestin-dependent signalling events. In the present article, we review current knowledge on structural and signalling properties of ACRs that are changing our view on this entire class of receptors from silent to endogenous β-arrestin-biased signalling receptors.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalBiochemical Society Transactions
Volume41
Issue number1
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Chemokine Receptors
Acoustic waves
Arrestin
Transcytosis
Bioactivity
Chemokines
Cell Movement
Leukocytes
Tissue
Ligands
Degradation

Keywords

  • β-arrestin
  • Atypical chemokine receptor
  • Chemokine
  • G-protein

ASJC Scopus subject areas

  • Biochemistry

Cite this

Atypical chemokine receptors : From silence to sound. / Cancellieri, Cinzia; Vacchini, Alessandro; Locati, Massimo; Bonecchi, Raffaella; Borroni, Elena M.

In: Biochemical Society Transactions, Vol. 41, No. 1, 02.2013, p. 231-236.

Research output: Contribution to journalArticle

Cancellieri, Cinzia ; Vacchini, Alessandro ; Locati, Massimo ; Bonecchi, Raffaella ; Borroni, Elena M. / Atypical chemokine receptors : From silence to sound. In: Biochemical Society Transactions. 2013 ; Vol. 41, No. 1. pp. 231-236.
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