Atypical chemokine receptors in cancer: Friends or foes?

Matteo Massara, Ornella Bonavita, Alberto Mantovani, Massimo Locati, Raffaella Bonecchi

Research output: Contribution to journalReview articlepeer-review


The chemokine system is a fundamental component of cancer-related inflammation involved in all stages of cancer development. It controls not only leukocyte infiltration in primary tumors but also angiogenesis, cancer cell proliferation, and migration to metastatic sites. Atypical chemokine receptors are a new, emerging class of regulators of the chemokine system. They control chemokine bioavailability by scavenging, transporting, or storing chemokines. They can also regulate the activity of canonical chemokine receptors with which they share the ligands by forming heterodimers or by modulating their expression levels or signaling activity. Here, we summarize recent results about the role of these receptors (atypical chemokine receptor 1/Duffy antigen receptor for chemokine, atypical chemokine receptor 2/D6, atypical chemokine receptor 3/CXC-chemokine receptor 7, and atypical chemokine receptor 4/CCchemokine receptor-like 1) on the tumorigenesis process, indicating that their effects are strictly dependent on the cell type on which they are expressed and on their coexpression with other chemokine receptors. Indeed, atypical chemokine receptors inhibit tumor growth and progression through their activity as negative regulators of chemokine bioavailability, whereas, on the contrary, they can promote tumorigenesis when they regulate the signaling of other chemokine receptors, such as CXCchemokine receptor 4. Thus, atypical chemokine receptors are key components of the regulatory network of inflammation and immunity in cancer and may have a major effect on anti-inflammatory and immunotherapeutic strategies.

Original languageEnglish
Pages (from-to)927-933
Number of pages7
JournalJournal of Leukocyte Biology
Issue number6
Publication statusPublished - Jun 1 2016


  • Cancer-related inflammation
  • Leukocytes
  • Metastasis
  • Tumor immunology

ASJC Scopus subject areas

  • Cell Biology
  • Immunology


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