TY - JOUR
T1 - Atypical cutaneous lesions in advanced-stage Hodgkin lymphoma: A case report
AU - Massaro, Fulvio
AU - Ferrari, Angela
AU - Zendri, Enrico
AU - Zanelli, Magda
AU - Merli, Francesco
PY - 2019/9/6
Y1 - 2019/9/6
N2 - BACKGROUND Cutaneous involvement in Hodgkin lymphoma (HL) is a rare finding. Few cases have been reported in literature, most describing paraneoplastic manifestations. Only very few papers have described primary HL skin infiltration, reporting a wide range of clinical presentations that frequently include ulcers; plaques, nodules and papules have also been noticed. CASE SUMMARY We report the case of a 56-year-old man who presented fever, multiple adenomegalies of neck and axilla and thick serpiginous skin lesions involving bilateral pectoral regions. After an initial diagnostic workup for a suspected active infectious disease, a lymph node biopsy was performed, which showed a neoplastic invasion from a mixed cellularity classical HL. The same histological pattern was described in a cutaneous biopsy of the chest lesions. The other staging procedures performed revealed an advanced disease, with unfavourable clinical prognostic features. The patient was prescribed 6 cycles of ABVD chemotherapy scheme (doxorubicin, bleomycin, vinblastine, dacarbazine), a regiment that requires demonstration of metabolic response achievement at the interim PET/CT scan to confirm continuation or to change therapeutic strategy. CONCLUSION Skin involvement in HL is a rare finding and may represent a challenging clinical presentation due to extremely various types of lesions observed.
AB - BACKGROUND Cutaneous involvement in Hodgkin lymphoma (HL) is a rare finding. Few cases have been reported in literature, most describing paraneoplastic manifestations. Only very few papers have described primary HL skin infiltration, reporting a wide range of clinical presentations that frequently include ulcers; plaques, nodules and papules have also been noticed. CASE SUMMARY We report the case of a 56-year-old man who presented fever, multiple adenomegalies of neck and axilla and thick serpiginous skin lesions involving bilateral pectoral regions. After an initial diagnostic workup for a suspected active infectious disease, a lymph node biopsy was performed, which showed a neoplastic invasion from a mixed cellularity classical HL. The same histological pattern was described in a cutaneous biopsy of the chest lesions. The other staging procedures performed revealed an advanced disease, with unfavourable clinical prognostic features. The patient was prescribed 6 cycles of ABVD chemotherapy scheme (doxorubicin, bleomycin, vinblastine, dacarbazine), a regiment that requires demonstration of metabolic response achievement at the interim PET/CT scan to confirm continuation or to change therapeutic strategy. CONCLUSION Skin involvement in HL is a rare finding and may represent a challenging clinical presentation due to extremely various types of lesions observed.
KW - ABVD
KW - Advanced stage
KW - Case report
KW - Hodgkin lymphoma
KW - Skin lesions
UR - http://www.scopus.com/inward/record.url?scp=85072327579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072327579&partnerID=8YFLogxK
U2 - 10.12998/wjcc.v7.i17.2513
DO - 10.12998/wjcc.v7.i17.2513
M3 - Article
C2 - 31559286
AN - SCOPUS:85072327579
VL - 7
SP - 2513
EP - 2518
JO - World Journal of Clinical Cases
JF - World Journal of Clinical Cases
SN - 2307-8960
IS - 17
ER -