Atypical cutaneous lesions in advanced-stage Hodgkin lymphoma: A case report

Fulvio Massaro, Angela Ferrari, Enrico Zendri, Magda Zanelli, Francesco Merli

Research output: Contribution to journalArticlepeer-review


BACKGROUND Cutaneous involvement in Hodgkin lymphoma (HL) is a rare finding. Few cases have been reported in literature, most describing paraneoplastic manifestations. Only very few papers have described primary HL skin infiltration, reporting a wide range of clinical presentations that frequently include ulcers; plaques, nodules and papules have also been noticed. CASE SUMMARY We report the case of a 56-year-old man who presented fever, multiple adenomegalies of neck and axilla and thick serpiginous skin lesions involving bilateral pectoral regions. After an initial diagnostic workup for a suspected active infectious disease, a lymph node biopsy was performed, which showed a neoplastic invasion from a mixed cellularity classical HL. The same histological pattern was described in a cutaneous biopsy of the chest lesions. The other staging procedures performed revealed an advanced disease, with unfavourable clinical prognostic features. The patient was prescribed 6 cycles of ABVD chemotherapy scheme (doxorubicin, bleomycin, vinblastine, dacarbazine), a regiment that requires demonstration of metabolic response achievement at the interim PET/CT scan to confirm continuation or to change therapeutic strategy. CONCLUSION Skin involvement in HL is a rare finding and may represent a challenging clinical presentation due to extremely various types of lesions observed.

Original languageEnglish
Pages (from-to)2513-2518
Number of pages6
JournalWorld Journal of Clinical Cases
Issue number17
Publication statusPublished - Sep 6 2019


  • ABVD
  • Advanced stage
  • Case report
  • Hodgkin lymphoma
  • Skin lesions

ASJC Scopus subject areas

  • Medicine(all)


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