Atypical ductal hyperplasia: Our experience in the management and long term clinical follow-up in 71 patients

Antuono Latronico, Luca Nicosia, Angela Faggian, Francesca Abbate, Silvia Penco, Anna Bozzini, Christine Cannataci, Giovanni Mazzarol, Enrico Cassano

Research output: Contribution to journalArticle

Abstract

Introduction Atypical ductal hyperplasia (ADH) is a high-risk benign lesion found in approximately 1–10% of breast biopsies and associated with a variable incidence of carcinoma after surgical excision. The main goal of our study is to present our experience in the management and long-term follow-up of 71 patients with ADH diagnosed on breast biopsy. Materials and methods Results of 3808 breast biopsy specimens from 1 January 2000 to 31 December 2005 were analyzed to identify all biopsies which resulted in a diagnosis of ADH. The histopathological results of the 45 patients who underwent surgery were analyzed. Long-term follow-up for the remaining patients was carried out. Results 45 of 71 (63.4%) patients with histological diagnosis of ADH on breast biopsy underwent surgery. Definitive histological results revealed invasive carcinoma in 7 cases (15.6%), high grade Ductal Carcinoma in situ (DCIS) in 10 (22.2%) patients, Lobular Carcinoma in situ (LCIS) in 4 cases (8.9%) and benign findings in 24 cases (53.3%). 12 of 71 (16.9%) patients underwent only long term follow-up; one (8,3%) of these developed invasive breast carcinoma after 6 years. Conclusion Atypical ductal hyperplasia diagnosed on breast biopsy is associated with a relatively high incidence of invasive carcinoma and high grade ductal carcinoma in situ at the time of surgical excision. Certain radiological and cytological criteria can be used to help determine which patients should forgo surgery and be followed up with good results. Long term follow-up is always crucial for patients who have not undergone surgery.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalBreast
Volume37
DOIs
Publication statusPublished - Feb 1 2018

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Carcinoma, Intraductal, Noninfiltrating
Breast
Biopsy
Carcinoma
Incidence
Breast Neoplasms

Keywords

  • Atypical ductal hyperplasia
  • Breast biopsy
  • Breast surgery
  • Follow up

ASJC Scopus subject areas

  • Surgery

Cite this

@article{f4ef441bb70d4981bc196e2d0e2387c9,
title = "Atypical ductal hyperplasia: Our experience in the management and long term clinical follow-up in 71 patients",
abstract = "Introduction Atypical ductal hyperplasia (ADH) is a high-risk benign lesion found in approximately 1–10{\%} of breast biopsies and associated with a variable incidence of carcinoma after surgical excision. The main goal of our study is to present our experience in the management and long-term follow-up of 71 patients with ADH diagnosed on breast biopsy. Materials and methods Results of 3808 breast biopsy specimens from 1 January 2000 to 31 December 2005 were analyzed to identify all biopsies which resulted in a diagnosis of ADH. The histopathological results of the 45 patients who underwent surgery were analyzed. Long-term follow-up for the remaining patients was carried out. Results 45 of 71 (63.4{\%}) patients with histological diagnosis of ADH on breast biopsy underwent surgery. Definitive histological results revealed invasive carcinoma in 7 cases (15.6{\%}), high grade Ductal Carcinoma in situ (DCIS) in 10 (22.2{\%}) patients, Lobular Carcinoma in situ (LCIS) in 4 cases (8.9{\%}) and benign findings in 24 cases (53.3{\%}). 12 of 71 (16.9{\%}) patients underwent only long term follow-up; one (8,3{\%}) of these developed invasive breast carcinoma after 6 years. Conclusion Atypical ductal hyperplasia diagnosed on breast biopsy is associated with a relatively high incidence of invasive carcinoma and high grade ductal carcinoma in situ at the time of surgical excision. Certain radiological and cytological criteria can be used to help determine which patients should forgo surgery and be followed up with good results. Long term follow-up is always crucial for patients who have not undergone surgery.",
keywords = "Atypical ductal hyperplasia, Breast biopsy, Breast surgery, Follow up",
author = "Antuono Latronico and Luca Nicosia and Angela Faggian and Francesca Abbate and Silvia Penco and Anna Bozzini and Christine Cannataci and Giovanni Mazzarol and Enrico Cassano",
year = "2018",
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T1 - Atypical ductal hyperplasia

T2 - Our experience in the management and long term clinical follow-up in 71 patients

AU - Latronico, Antuono

AU - Nicosia, Luca

AU - Faggian, Angela

AU - Abbate, Francesca

AU - Penco, Silvia

AU - Bozzini, Anna

AU - Cannataci, Christine

AU - Mazzarol, Giovanni

AU - Cassano, Enrico

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Introduction Atypical ductal hyperplasia (ADH) is a high-risk benign lesion found in approximately 1–10% of breast biopsies and associated with a variable incidence of carcinoma after surgical excision. The main goal of our study is to present our experience in the management and long-term follow-up of 71 patients with ADH diagnosed on breast biopsy. Materials and methods Results of 3808 breast biopsy specimens from 1 January 2000 to 31 December 2005 were analyzed to identify all biopsies which resulted in a diagnosis of ADH. The histopathological results of the 45 patients who underwent surgery were analyzed. Long-term follow-up for the remaining patients was carried out. Results 45 of 71 (63.4%) patients with histological diagnosis of ADH on breast biopsy underwent surgery. Definitive histological results revealed invasive carcinoma in 7 cases (15.6%), high grade Ductal Carcinoma in situ (DCIS) in 10 (22.2%) patients, Lobular Carcinoma in situ (LCIS) in 4 cases (8.9%) and benign findings in 24 cases (53.3%). 12 of 71 (16.9%) patients underwent only long term follow-up; one (8,3%) of these developed invasive breast carcinoma after 6 years. Conclusion Atypical ductal hyperplasia diagnosed on breast biopsy is associated with a relatively high incidence of invasive carcinoma and high grade ductal carcinoma in situ at the time of surgical excision. Certain radiological and cytological criteria can be used to help determine which patients should forgo surgery and be followed up with good results. Long term follow-up is always crucial for patients who have not undergone surgery.

AB - Introduction Atypical ductal hyperplasia (ADH) is a high-risk benign lesion found in approximately 1–10% of breast biopsies and associated with a variable incidence of carcinoma after surgical excision. The main goal of our study is to present our experience in the management and long-term follow-up of 71 patients with ADH diagnosed on breast biopsy. Materials and methods Results of 3808 breast biopsy specimens from 1 January 2000 to 31 December 2005 were analyzed to identify all biopsies which resulted in a diagnosis of ADH. The histopathological results of the 45 patients who underwent surgery were analyzed. Long-term follow-up for the remaining patients was carried out. Results 45 of 71 (63.4%) patients with histological diagnosis of ADH on breast biopsy underwent surgery. Definitive histological results revealed invasive carcinoma in 7 cases (15.6%), high grade Ductal Carcinoma in situ (DCIS) in 10 (22.2%) patients, Lobular Carcinoma in situ (LCIS) in 4 cases (8.9%) and benign findings in 24 cases (53.3%). 12 of 71 (16.9%) patients underwent only long term follow-up; one (8,3%) of these developed invasive breast carcinoma after 6 years. Conclusion Atypical ductal hyperplasia diagnosed on breast biopsy is associated with a relatively high incidence of invasive carcinoma and high grade ductal carcinoma in situ at the time of surgical excision. Certain radiological and cytological criteria can be used to help determine which patients should forgo surgery and be followed up with good results. Long term follow-up is always crucial for patients who have not undergone surgery.

KW - Atypical ductal hyperplasia

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KW - Follow up

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