Atypical fibroxanthoma is an uncommon neoplasm of the superficial soft tissue which typically arises in sun-damaged skin of the head and neck region in the elderly. It is a cytologically malignant but usually clinically benign lesion. We describe a case of atypical fibroxanthoma of the scalp in an aged man (85 years). At first observation (July 1994) the patient showed a compact-elastic nodule of maximum diameter 2 cm, showing foci of central necrosis. The lesion recurred 1 year after surgical therapy. Morphologic observation confirmed the previous diagnosis of atypical fibroxanthoma. The cellular dermal infiltrate was composed of cells with pleomorphic, hyperchromatic nuclei in an irregular arrangement. There were large, bizarre, multinucleated giant cells showing marked nuclear atypicality. Many mitoses were present, some of them atypical in appearance. The immunohistochemical study demonstrated only vimentin positivity. Keratin and S-100 protein were negative. A new wide surgical excision was necessary and currently (six months later) the patient is free of pathology.
|Translated title of the contribution||Atypical fibroxanthoma of the scalp|
|Number of pages||3|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1997|
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