Atypical language lateralization and early linguistic development in children with focal brain lesions

A. M. Chilosi, C. Pecini, P. Cipriani, P. Brovedani, D. Brizzolara, G. Ferretti, L. Pfanner, G. Cioni

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of congenital, unilateral, focal brain lesions on early linguistic development and hemispheric lateralization for language were investigated longitudinally in 24 preschool children with hemiplegia(14 males, 10 females), 12 with left hemisphere damage (LHD) and 12 with right hemisphere damage (RHD). A comprehensive linguistic assessment was performed at 2 and 3 years of life; cerebral lateralization for language was measured by the Fused Dichotic Words Listening Test. An early left-side specificity for language was indicated by the presence of lexical and grammatical delay in most children with LHD. In the dichotic listening test all 12 children with LHD showed a shift of language lateralization from the left to the right hemisphere. Atypical lateralization coefficients (lambda), i.e. values falling more than two standard deviations from the mean of a normative sample, were associated with a delay in lexical and grammatical development, especially after LHD. In addition, cortical-subcortical-periventricular lesions rather than solely periventricular damage, and larger lesions rather than small, were associated with the most atypical lateralization coefficients, irrespective of lesion side. Results of this study suggest that language and lateralization data are closely related and that reallocation of language functions in alternative regions of the brain has a cost in terms of a slow rate of language acquisition.

Original languageEnglish
Pages (from-to)725-730
Number of pages6
JournalDevelopmental Medicine and Child Neurology
Volume47
Issue number11
DOIs
Publication statusPublished - Nov 2005

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Atypical language lateralization and early linguistic development in children with focal brain lesions'. Together they form a unique fingerprint.

Cite this