Abstract
Purpose of review: Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA2 and others are present in this abnormal genetic material. Recent findings: In the past few years, several papers have further dissected the genetic alterations present in these tumors, allowing the identification of new potential oncogenes. Summary: ALT/WDLs represent therefore an interesting model for assessing the potential role of these oncogenes, not only in the pathogenesis, but also as a therapeutic target.
| Original language | English |
|---|---|
| Pages (from-to) | 355-358 |
| Number of pages | 4 |
| Journal | Current Opinion in Oncology |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2004 |
Keywords
- Atypical lipomatous tumor
- Genetic alterations
- MDM2
- Well-differentiated liposarcoma
ASJC Scopus subject areas
- Cancer Research
Fingerprint Dive into the research topics of 'Atypical lipomatous tumor: Molecular characterization'. Together they form a unique fingerprint.
Cite this
Arrigoni, G., & Doglioni, C. (2004). Atypical lipomatous tumor: Molecular characterization. Current Opinion in Oncology, 16(4), 355-358. https://doi.org/10.1097/01.cco.0000127878.85125.53