TY - JOUR
T1 - Atypical lipomatous tumor
T2 - Molecular characterization
AU - Arrigoni, Gianluigi
AU - Doglioni, Claudio
PY - 2004/7
Y1 - 2004/7
N2 - Purpose of review: Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA2 and others are present in this abnormal genetic material. Recent findings: In the past few years, several papers have further dissected the genetic alterations present in these tumors, allowing the identification of new potential oncogenes. Summary: ALT/WDLs represent therefore an interesting model for assessing the potential role of these oncogenes, not only in the pathogenesis, but also as a therapeutic target.
AB - Purpose of review: Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA2 and others are present in this abnormal genetic material. Recent findings: In the past few years, several papers have further dissected the genetic alterations present in these tumors, allowing the identification of new potential oncogenes. Summary: ALT/WDLs represent therefore an interesting model for assessing the potential role of these oncogenes, not only in the pathogenesis, but also as a therapeutic target.
KW - Atypical lipomatous tumor
KW - Genetic alterations
KW - MDM2
KW - Well-differentiated liposarcoma
UR - http://www.scopus.com/inward/record.url?scp=3042806948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042806948&partnerID=8YFLogxK
U2 - 10.1097/01.cco.0000127878.85125.53
DO - 10.1097/01.cco.0000127878.85125.53
M3 - Article
C2 - 15187890
AN - SCOPUS:3042806948
VL - 16
SP - 355
EP - 358
JO - Current Opinion in Oncology
JF - Current Opinion in Oncology
SN - 1040-8746
IS - 4
ER -