Atypical lipomatous tumor: Molecular characterization

Gianluigi Arrigoni, Claudio Doglioni

Research output: Contribution to journalArticle

Abstract

Purpose of review: Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA2 and others are present in this abnormal genetic material. Recent findings: In the past few years, several papers have further dissected the genetic alterations present in these tumors, allowing the identification of new potential oncogenes. Summary: ALT/WDLs represent therefore an interesting model for assessing the potential role of these oncogenes, not only in the pathogenesis, but also as a therapeutic target.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalCurrent Opinion in Oncology
Volume16
Issue number4
DOIs
Publication statusPublished - Jul 2004

Keywords

  • Atypical lipomatous tumor
  • Genetic alterations
  • MDM2
  • Well-differentiated liposarcoma

ASJC Scopus subject areas

  • Cancer Research

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