Abstract
Purpose of review: Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA2 and others are present in this abnormal genetic material. Recent findings: In the past few years, several papers have further dissected the genetic alterations present in these tumors, allowing the identification of new potential oncogenes. Summary: ALT/WDLs represent therefore an interesting model for assessing the potential role of these oncogenes, not only in the pathogenesis, but also as a therapeutic target.
| Original language | English |
|---|---|
| Pages (from-to) | 355-358 |
| Number of pages | 4 |
| Journal | Current Opinion in Oncology |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2004 |
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Keywords
- Atypical lipomatous tumor
- Genetic alterations
- MDM2
- Well-differentiated liposarcoma
ASJC Scopus subject areas
- Cancer Research
Cite this
Atypical lipomatous tumor : Molecular characterization. / Arrigoni, Gianluigi; Doglioni, Claudio.
In: Current Opinion in Oncology, Vol. 16, No. 4, 07.2004, p. 355-358.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Atypical lipomatous tumor
T2 - Molecular characterization
AU - Arrigoni, Gianluigi
AU - Doglioni, Claudio
PY - 2004/7
Y1 - 2004/7
N2 - Purpose of review: Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA2 and others are present in this abnormal genetic material. Recent findings: In the past few years, several papers have further dissected the genetic alterations present in these tumors, allowing the identification of new potential oncogenes. Summary: ALT/WDLs represent therefore an interesting model for assessing the potential role of these oncogenes, not only in the pathogenesis, but also as a therapeutic target.
AB - Purpose of review: Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA2 and others are present in this abnormal genetic material. Recent findings: In the past few years, several papers have further dissected the genetic alterations present in these tumors, allowing the identification of new potential oncogenes. Summary: ALT/WDLs represent therefore an interesting model for assessing the potential role of these oncogenes, not only in the pathogenesis, but also as a therapeutic target.
KW - Atypical lipomatous tumor
KW - Genetic alterations
KW - MDM2
KW - Well-differentiated liposarcoma
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UR - http://www.scopus.com/inward/citedby.url?scp=3042806948&partnerID=8YFLogxK
U2 - 10.1097/01.cco.0000127878.85125.53
DO - 10.1097/01.cco.0000127878.85125.53
M3 - Article
VL - 16
SP - 355
EP - 358
JO - Current Opinion in Oncology
JF - Current Opinion in Oncology
SN - 1040-8746
IS - 4
ER -