Atypical myeloproliferative disorder associated with a 21 trisomic clone

Giorgio Ponzio, Massimo Aglietta, Wanda Piacibello, Mario De Marchi, Angelo O. Carbonara

Research output: Contribution to journalArticlepeer-review


The hematological and cytogenetical studies of a case of atypical myeloproliferative disorder are reported. The patient displayed moderate leukocytosis, anemia and thrombocytopenia. Reduced or absent growth of CFU-C was observed in the bone marrow and peripheral blood. The cytogenetical analysis revealed a trisomy 21 limited to the neoplastic clone. The overall results are discussed and compared with the rare cases of acquired trisomy 21 reported in the literature.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalLa Ricerca in Clinica e in Laboratorio
Issue number2
Publication statusPublished - Apr 1981


  • Chromosomal banding
  • Chromosomal marker
  • Chronic myeloid leukemia
  • Myeloproliferative disorder
  • Trisomy 21 clone

ASJC Scopus subject areas

  • Clinical Biochemistry


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