Atypical Spitz tumours and sentinel lymph node biopsy: A systematic review

Aimilios Lallas, Athanassios Kyrgidis, Gerardo Ferrara, Harald Kittler, Zoe Apalla, Fabio Castagnetti, Caterina Longo, Elvira Moscarella, Simonetta Piana, Iris Zalaudek, Giuseppe Argenziano

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Abstract

Sentinel lymph node biopsy has been proposed as a diagnostic method for estimation of the malignant potential of atypical Spitz tumours. However, although cell deposits are commonly detected in the sentinel lymph nodes of patients with atypical Spitz tumours, their prognosis is substantially better than that of patients with melanoma and positive sentinel lymph node biopsies. We did a systematic review of published reports to assess the role of sentinel lymph node biopsy as a prognostic method in the management of atypical Spitz tumours. The results of our analysis did not show any prognostic benefit of sentinel lymph node biopsy; having a positive sentinel lymph node does not seem to predict a poorer outcome for patients with atypical Spitz tumours. These findings indicate that, especially in the paediatric population, it might be prudent initially to use complete excision with clear margins and careful clinical follow-up in patients with atypical Spitz tumours.

Original languageEnglish
JournalThe Lancet Oncology
Volume15
Issue number4
DOIs
Publication statusPublished - 2014

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Sentinel Lymph Node Biopsy
Neoplasms
Melanoma
Pediatrics
Population

ASJC Scopus subject areas

  • Oncology

Cite this

Atypical Spitz tumours and sentinel lymph node biopsy : A systematic review. / Lallas, Aimilios; Kyrgidis, Athanassios; Ferrara, Gerardo; Kittler, Harald; Apalla, Zoe; Castagnetti, Fabio; Longo, Caterina; Moscarella, Elvira; Piana, Simonetta; Zalaudek, Iris; Argenziano, Giuseppe.

In: The Lancet Oncology, Vol. 15, No. 4, 2014.

Research output: Contribution to journalArticle

Lallas, A, Kyrgidis, A, Ferrara, G, Kittler, H, Apalla, Z, Castagnetti, F, Longo, C, Moscarella, E, Piana, S, Zalaudek, I & Argenziano, G 2014, 'Atypical Spitz tumours and sentinel lymph node biopsy: A systematic review', The Lancet Oncology, vol. 15, no. 4. https://doi.org/10.1016/S1470-2045(13)70608-9
Lallas, Aimilios ; Kyrgidis, Athanassios ; Ferrara, Gerardo ; Kittler, Harald ; Apalla, Zoe ; Castagnetti, Fabio ; Longo, Caterina ; Moscarella, Elvira ; Piana, Simonetta ; Zalaudek, Iris ; Argenziano, Giuseppe. / Atypical Spitz tumours and sentinel lymph node biopsy : A systematic review. In: The Lancet Oncology. 2014 ; Vol. 15, No. 4.
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AU - Castagnetti, Fabio

AU - Longo, Caterina

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