"Atypical steroid response" in a pulmonary inflammatory myofibroblastic tumor

Oliviero Sacco; Claudio Gambini; Chiara Gardella; Paolo Tomà; Umberto G. Rossi; Vincenzo Jasonni; Andrew Bush; Giovanni A. Rossi

doi:10.1002/ppul.21237

"Atypical steroid response" in a pulmonary inflammatory myofibroblastic tumor

Oliviero Sacco, Claudio Gambini, Chiara Gardella, Paolo Tomà, Umberto G. Rossi, Vincenzo Jasonni, Andrew Bush, Giovanni A. Rossi

Research output: Contribution to journal › Article › peer-review

Abstract

A 6-year-old girl was evaluated for the presence of a paratracheal mass with right upper lobe atelectasis due to an endobronchial mass. Bronchoscopic biopsy established a diagnosis of inflammatory myofibroblastic tumor (IMT) and prednisone initially led to a significant reduction of the endobronchial lesion. However, 8 weeks later, when still on prednisone, the mediastinal mass enlarged dramatically. At thoracotomy, a well-circumscribed, multilobulated mass was partially resected and a diagnosis of IMT confirmed. Immunosuppression by corticosteroids may have favored the rapid progression of this apparently benign, indolent tumor.

Original language	English
Pages (from-to)	721-726
Number of pages	6
Journal	Pediatric Pulmonology
Volume	45
Issue number	7
DOIs	https://doi.org/10.1002/ppul.21237
Publication status	Published - Jul 2010

Keywords

Atelectasis
Inflammatory myofibroblastic tumor
Mediastinal mass
Plasma cell granuloma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

Access to Document

10.1002/ppul.21237

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title = "{"}Atypical steroid response{"} in a pulmonary inflammatory myofibroblastic tumor",

abstract = "A 6-year-old girl was evaluated for the presence of a paratracheal mass with right upper lobe atelectasis due to an endobronchial mass. Bronchoscopic biopsy established a diagnosis of inflammatory myofibroblastic tumor (IMT) and prednisone initially led to a significant reduction of the endobronchial lesion. However, 8 weeks later, when still on prednisone, the mediastinal mass enlarged dramatically. At thoracotomy, a well-circumscribed, multilobulated mass was partially resected and a diagnosis of IMT confirmed. Immunosuppression by corticosteroids may have favored the rapid progression of this apparently benign, indolent tumor.",

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AU - Sacco, Oliviero

AU - Gambini, Claudio

AU - Gardella, Chiara

AU - Tomà, Paolo

AU - Rossi, Umberto G.

AU - Jasonni, Vincenzo

AU - Bush, Andrew

AU - Rossi, Giovanni A.

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