TY - JOUR
T1 - Atypical tentorial meningioma 30 years after radiotherapy for a pituitary adenoma
AU - Santoro, A.
AU - Minniti, G.
AU - Paolini, S.
AU - Passacantilli, E.
AU - Missori, P.
AU - Frati, A.
AU - Cantore, G. P.
PY - 2002
Y1 - 2002
N2 - Although the human central nervous system used to be considered relatively resistant to the carcinogenic action of ionizing radiation, several lines of evidence now document a high incidence of secondary tumors in irradiated patients. The numerous reports of radiation-induced cerebral meningiomas generally distinguish those induced by high-dose radiation from those induced by low-dose radiation. We describe the case of patient who underwent subtotal resection of a chromophobe pituitary adenoma at the age of 18 years, who was successively treated by conventional fractionated radiotherapy with gamma rays emitted by a source of 60Co until a total dose of 41 Gy. Over the next 30 years the patient experienced all the known late effects of radiation, including panhypopituitarism, cranial-nerve deficits (II, III and VI), massive radiation necrosis involving the left cerebral hemisphere and causing right hemiparesis and aphasia and, ultimately, an atypical tentorial meningioma with early recurrence after total resection.
AB - Although the human central nervous system used to be considered relatively resistant to the carcinogenic action of ionizing radiation, several lines of evidence now document a high incidence of secondary tumors in irradiated patients. The numerous reports of radiation-induced cerebral meningiomas generally distinguish those induced by high-dose radiation from those induced by low-dose radiation. We describe the case of patient who underwent subtotal resection of a chromophobe pituitary adenoma at the age of 18 years, who was successively treated by conventional fractionated radiotherapy with gamma rays emitted by a source of 60Co until a total dose of 41 Gy. Over the next 30 years the patient experienced all the known late effects of radiation, including panhypopituitarism, cranial-nerve deficits (II, III and VI), massive radiation necrosis involving the left cerebral hemisphere and causing right hemiparesis and aphasia and, ultimately, an atypical tentorial meningioma with early recurrence after total resection.
KW - Meningioma
KW - Pituitary adenoma
KW - Radiotherapy
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U2 - 10.1007/s100720200007
DO - 10.1007/s100720200007
M3 - Article
C2 - 11976979
AN - SCOPUS:0036229001
VL - 22
SP - 463
EP - 467
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -