Au nanoparticle-based sensor for apomorphine detection in plasma

Chiara Zanchi, Andrea Lucotti, Matteo Tommasini, Sebastiano Trusso, Ugo de Grazia, Emilio Ciusani, Paolo M. Ossi

Research output: Contribution to journalArticlepeer-review

Abstract

Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentration range between 3.3 × 10-4 M and 3.3 × 10-7 M. The experimental parameters have been investigated and the dynamic concentration range of the sensor has been assessed by the selection of two apomorphine surface enhanced Raman scattering (SERS) peaks. The sensor behavior used to detect apomorphine in unfiltered human blood plasma is presented and discussed.

Original languageEnglish
Pages (from-to)2224-2232
Number of pages9
JournalBeilstein Journal of Nanotechnology
Volume6
DOIs
Publication statusPublished - 2015

Keywords

  • Apomorphine
  • Au NPs
  • Nano-roughened films
  • Pulsed laser deposition
  • Self-assembled films
  • SERS

ASJC Scopus subject areas

  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Physics and Astronomy(all)

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