TY - JOUR
T1 - Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of alzheimer’s disease
AU - Paciello, Fabiola
AU - Rinaudo, Marco
AU - Longo, Valentina
AU - Cocco, Sara
AU - Conforto, Giulia
AU - Pisani, Anna
AU - Podda, Maria Vittoria
AU - Fetoni, Anna Rita
AU - Paludetti, Gaetano
AU - Grassi, Claudio
N1 - Funding Information:
This work was supported by BRiC INAIL 2016-DiMEILA17, INAIL Bando BRIC 09. Università Cattolica del Sacro Cuore contributed to the funding of this research project and its publication (D1, D3.1 intramural funds). Confocal analysis was performed at the 'Labcemi' facility of the same University.
Publisher Copyright:
© Paciello et al.
PY - 2021/10
Y1 - 2021/10
N2 - Although association between hearing impairment and dementia has been widely documented by epidemiological studies, the role of auditory sensory deprivation in cognitive decline remains to be fully understood. To address this issue we investigated the impact of hearing loss on the onset and time-course of cognitive decline in an animal model of Alzheimer’s disease (AD), that is the 3×Tg-AD mice and the underlying mechanisms. We found that hearing loss induced by noise exposure in the 3×Tg-AD mice before the phenotype is manifested caused persistent synaptic and morphological alterations in the auditory cortex. This was associated with earlier hippocampal dysfunction, increased tau phosphorylation, neuroinflammation, and redox imbalance, along with anticipated memory deficits compared to the expected time-course of the neurodegenerative phenotype. Our data suggest that a mouse model of AD is more vulnerable to central damage induced by hearing loss and shows reduced ability to counteract noise-induced detrimental effects, which accelerates the neurodegenerative disease onset.
AB - Although association between hearing impairment and dementia has been widely documented by epidemiological studies, the role of auditory sensory deprivation in cognitive decline remains to be fully understood. To address this issue we investigated the impact of hearing loss on the onset and time-course of cognitive decline in an animal model of Alzheimer’s disease (AD), that is the 3×Tg-AD mice and the underlying mechanisms. We found that hearing loss induced by noise exposure in the 3×Tg-AD mice before the phenotype is manifested caused persistent synaptic and morphological alterations in the auditory cortex. This was associated with earlier hippocampal dysfunction, increased tau phosphorylation, neuroinflammation, and redox imbalance, along with anticipated memory deficits compared to the expected time-course of the neurodegenerative phenotype. Our data suggest that a mouse model of AD is more vulnerable to central damage induced by hearing loss and shows reduced ability to counteract noise-induced detrimental effects, which accelerates the neurodegenerative disease onset.
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U2 - 10.7554/eLife.70908
DO - 10.7554/eLife.70908
M3 - Article
AN - SCOPUS:85118225888
VL - 10
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e70908
ER -