Augmentation of restless legs syndrome with long-term tramadol treatment

Roberto Vetrugno, Chiara La Morgia, Roberto D'Angelo, Daniela Loi, Federica Provini, Giuseppe Plazzi, Pasquale Montagna

Research output: Contribution to journalArticle

Abstract

Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnography accounts of a patient developing RLS augmentation after long-term treatment with tramadol, an opioid agonist with selectivity for μ-receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnography measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs.

Original languageEnglish
Pages (from-to)424-427
Number of pages4
JournalMovement Disorders
Volume22
Issue number3
DOIs
Publication statusPublished - Feb 15 2007

Fingerprint

Restless Legs Syndrome
Tramadol
Dopamine Agents
Polysomnography
Therapeutics
Serotonin Receptors
Circadian Rhythm
Human Body
Adrenergic Receptors
Opioid Analgesics

Keywords

  • Augmentation
  • Opioids
  • Polysomnography
  • Restless legs syndrome
  • Tramadol

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Augmentation of restless legs syndrome with long-term tramadol treatment. / Vetrugno, Roberto; La Morgia, Chiara; D'Angelo, Roberto; Loi, Daniela; Provini, Federica; Plazzi, Giuseppe; Montagna, Pasquale.

In: Movement Disorders, Vol. 22, No. 3, 15.02.2007, p. 424-427.

Research output: Contribution to journalArticle

Vetrugno, Roberto ; La Morgia, Chiara ; D'Angelo, Roberto ; Loi, Daniela ; Provini, Federica ; Plazzi, Giuseppe ; Montagna, Pasquale. / Augmentation of restless legs syndrome with long-term tramadol treatment. In: Movement Disorders. 2007 ; Vol. 22, No. 3. pp. 424-427.
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