Augmentation strategy with olanzapine in resistant obsessive compulsive disorder: An Italian long-term open-label study

Donatella Marazziti, Chiara Pfanner, Bernardo Dell'Osso, Antonio Ciapparelli, Silvio Presta, Giorgio Corretti, Elena Di Nasso, Francesco Mungai, Liliana Dell'Osso

Research output: Contribution to journalArticlepeer-review

Abstract

The present study reports the results of an open-label trial on the use of the combination of olanzapine (an atypical antipsychotic) + serotonin reuptake inhibitors (SRIs) in 26 resistant outpatients affected by resistant obsessive-compulsive disorder (OCD). All patients had been suffering from OCD, according to DSM IV criteria, for at least 2 years and had different comorbid disorders; they had been treated with an SRI at adequate dosages for at least 6 months, or had tried different augmentation strategies with no or poor response. As a result, olanzapine was added and continued for 1 year. After 12 weeks of this regimen, most of the patients (17) had shown a reduction in OC symptoms, as assessed by a decrease in the Yale-Brown Obsessive Compulsive Scale total score, which continued throughout subsequent months. Only mild side-effects were recorded and no patient halted the treatment. The addition of olanzapine would appear to be a useful short- and long-term strategy for augmenting SRI effectiveness in resistant OCD patients, especially in those presenting comorbidity with bipolar disorders.

Original languageEnglish
Pages (from-to)392-394
Number of pages3
JournalJournal of Psychopharmacology
Volume19
Issue number4
DOIs
Publication statusPublished - Jul 2005

Keywords

  • Atypical neuroleptics
  • Augmentation strategies
  • Obsessive-compulsive disorder
  • Olanzapine
  • Serotonin re-uptake inhibitors

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Neuroscience(all)

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