Augmentative repetitive Transcranial Magnetic Stimulation (rTMS) in the acute treatment of poor responder depressed patients: A comparison study between high and low frequency stimulation

B. Dell'Osso, L. Oldani, G. Camuri, C. Dobrea, L. Cremaschi, B. Benatti, C. Arici, B. Grancini, A. Carlo Altamura

Research output: Contribution to journalArticle

Abstract

Background: While the efficacy of repetitive transcranial magnetic stimulation (rTMS) in Major Depressive Disorder (MDD) is well established, the debate is still open in relation to bipolar depression and to a possible different effectiveness of high vs. low stimulation. The present study was aimed to assess and compare the efficacy and tolerability of different protocols of augmentative rTMS in a sample of patients with current Major Depressive Episode (MDE), poor drug response/treatment resistance and a diagnosis of MDD or bipolar disorder. Methods: Thirty-three patients were recruited in a 4-week, blind-rater, rTMS trial and randomised to the following three groups of stimulation: (1) ( n= 10) right dorsolateral prefrontal cortex (DLPFC) 1 HZ, 110% of the motor threshold (MT), 420 stimuli/day; (2) ( n= 10) right DLPFC, 1. Hz, 110% MT, 900 stimuli/day; (3) ( n= 13) left DLPFC, 10. Hz, 80% MT, 750 stimuli/day. Results: Twenty-nine patients completed the treatment, showing a significant reduction of primary outcome measures (HAM-D, MADRS and CGI-S total scores: t= 8.1, P

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalEuropean Psychiatry
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Augmentation
  • Bipolar disorder
  • Major depressive disorder
  • Poor drug response
  • Repetitive transcranial magnetic stimulation (rTMS)
  • Treatment resistance

ASJC Scopus subject areas

  • Psychiatry and Mental health

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