Abstract
The efficacy of transcranial magnetic stimulation (TMS) has been poorly investigated in the acute and maintenance treatment of bipolar depression. The present case supports the efficacy of low-frequency repetitive TMS (rTMS) of the right dorsolateral pre-frontal cortex (RDLPFC) combined to brain navigation in a drug-resistant, bipolar depressed subject with rapid cycling. While continuing the pharmacological treatment at stable doses, the patient was stimulated for 3 weeks at 1 Hz, 110% of motor threshold, 300 stimuli/day showing a significant improvement on the Hamilton Depression Rating Scale (HDRS21), the MontgomeryAsberg Depression Rating Scale (MADRS) and the Clinical Global Impression, improvement scale (CGI-I) total scores. On completion of the 3-week rTMS, the patient was treated with periodic maintenance sessions of rTMS at the same parameters of acute phase for an additional 6 months, at the end of which the therapeutic gains were maintained according to rating scales scores. Larger controlled trials assessing the acute and maintenance efficacy of rTMS in bipolar depression are needed.
| Original language | English |
|---|---|
| Pages (from-to) | 673-676 |
| Number of pages | 4 |
| Journal | World Journal of Biological Psychiatry |
| Volume | 10 |
| Issue number | 4 PART 2 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Bipolar depression
- Brain navigation
- Right dorsolateral pre-frontal cortex (RDLPFC)
- Transcranial magnetic stimulation (TMS)
ASJC Scopus subject areas
- Medicine(all)
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Augmentative transcranial magnetic stimulation (TMS) combined with brain navigation in drug-resistant rapid cycling bipolar depression : A case report of acute and maintenance efficacy. / Dell'Osso, Bernardo; Altamura, A. Carlo.
In: World Journal of Biological Psychiatry, Vol. 10, No. 4 PART 2, 2009, p. 673-676.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Augmentative transcranial magnetic stimulation (TMS) combined with brain navigation in drug-resistant rapid cycling bipolar depression
T2 - A case report of acute and maintenance efficacy
AU - Dell'Osso, Bernardo
AU - Altamura, A. Carlo
PY - 2009
Y1 - 2009
N2 - The efficacy of transcranial magnetic stimulation (TMS) has been poorly investigated in the acute and maintenance treatment of bipolar depression. The present case supports the efficacy of low-frequency repetitive TMS (rTMS) of the right dorsolateral pre-frontal cortex (RDLPFC) combined to brain navigation in a drug-resistant, bipolar depressed subject with rapid cycling. While continuing the pharmacological treatment at stable doses, the patient was stimulated for 3 weeks at 1 Hz, 110% of motor threshold, 300 stimuli/day showing a significant improvement on the Hamilton Depression Rating Scale (HDRS21), the MontgomeryAsberg Depression Rating Scale (MADRS) and the Clinical Global Impression, improvement scale (CGI-I) total scores. On completion of the 3-week rTMS, the patient was treated with periodic maintenance sessions of rTMS at the same parameters of acute phase for an additional 6 months, at the end of which the therapeutic gains were maintained according to rating scales scores. Larger controlled trials assessing the acute and maintenance efficacy of rTMS in bipolar depression are needed.
AB - The efficacy of transcranial magnetic stimulation (TMS) has been poorly investigated in the acute and maintenance treatment of bipolar depression. The present case supports the efficacy of low-frequency repetitive TMS (rTMS) of the right dorsolateral pre-frontal cortex (RDLPFC) combined to brain navigation in a drug-resistant, bipolar depressed subject with rapid cycling. While continuing the pharmacological treatment at stable doses, the patient was stimulated for 3 weeks at 1 Hz, 110% of motor threshold, 300 stimuli/day showing a significant improvement on the Hamilton Depression Rating Scale (HDRS21), the MontgomeryAsberg Depression Rating Scale (MADRS) and the Clinical Global Impression, improvement scale (CGI-I) total scores. On completion of the 3-week rTMS, the patient was treated with periodic maintenance sessions of rTMS at the same parameters of acute phase for an additional 6 months, at the end of which the therapeutic gains were maintained according to rating scales scores. Larger controlled trials assessing the acute and maintenance efficacy of rTMS in bipolar depression are needed.
KW - Bipolar depression
KW - Brain navigation
KW - Right dorsolateral pre-frontal cortex (RDLPFC)
KW - Transcranial magnetic stimulation (TMS)
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UR - http://www.scopus.com/inward/citedby.url?scp=77449104539&partnerID=8YFLogxK
U2 - 10.1080/15622970701806192
DO - 10.1080/15622970701806192
M3 - Article
C2 - 18956262
AN - SCOPUS:77449104539
VL - 10
SP - 673
EP - 676
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
SN - 1562-2975
IS - 4 PART 2
ER -