Augmented type 1 cytokines and human endogenous retroviruses specific immune responses in patients with acute multiple sclerosis

Daria Trabattoni, Pasquale Ferrante, Maria Luisa Fusi, Marina Saresella, Domenico Caputo, Howard Urnovitz, Carlo Luigi Cazzullo, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro antigen- and mitogen-stimulated cytokine production were analysed in multiple sclerosis (MS) patients with either acute (AMS) or stable (SMS) disease and in healthy controls (HC). We also investigated whether immune responses to human endogenous retroviruses (HERV) could be detected in MS and whether these immune responses would be correlated with disease status by analysing cytokine production after stimulation of PBMC with HERV peptides. Results showed that mitogen-stimulated IL-2 and IFN-γ was augmented and IL-10 was decreased in AMS compared to both SMS and healthy controls. Whereas the production of the metabolically active IL-12 (p70 heterodimer), was comparable in SMS, AMS and HC, production of the total IL-12 (p70 heterodimer and the p40 chain) were augmented in SMS compared to both AMS and HC. HERV-peptides IL-2 and IFN-γ production was more frequent and more potent in AMS compared to both SMS patients and HC. HERV-specific type 2 cytokine production was more frequent and potent in SMS compared to AMS and HC. Thus a prevalent type 1 cytokine profile was seen in AMS patients, while IL-10 production predominated in SMS individuals.

Original languageEnglish
JournalJournal of NeuroVirology
Volume6
Issue numberSUPPL. 2
Publication statusPublished - 2000

Keywords

  • Cytokines
  • HERV
  • Multiple sclerosis

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

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