Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression

Laura Casorzo, Carmine Dell'Aglio, Ivana Sarotto, Mauro Risio

Research output: Contribution to journalArticle

Abstract

A crucial role for Aurora Kinase A (AURKA) gene has been demonstrated in the advanced steps of colorectal tumor progression. Little is known, however, about its role in the early phases of the adenoma-carcinoma sequence. Moreover, no data are currently available concerning AURKA involvement in the serrated tumorigenesis. Fluorescence in situ hybridization analysis and immunohistochemistry were used to assess gene copy number and protein expression in 40 colorectal adenomas, 20 cancerized adenomas, and 20 serrated polyps. An increased copy number was found either in adenomatous tissue or in early cancer in the vast majority of cancerized adenomas, but only in 5% of adenomas (P

Original languageEnglish
Pages (from-to)411-418
Number of pages8
JournalHuman Pathology
Volume46
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

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Aurora Kinase A
Gene Dosage
Adenoma
Neoplasms
Polyps
Fluorescence In Situ Hybridization
Colorectal Neoplasms
Carcinogenesis
Immunohistochemistry
Carcinoma
Genes
Proteins

Keywords

  • AURKA gene
  • Cancerized adenoma
  • Colorectal adenomas
  • Serrated polyps
  • Tumor progression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression. / Casorzo, Laura; Dell'Aglio, Carmine; Sarotto, Ivana; Risio, Mauro.

In: Human Pathology, Vol. 46, No. 3, 01.03.2015, p. 411-418.

Research output: Contribution to journalArticle

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