Abstract
A crucial role for Aurora Kinase A (AURKA) gene has been demonstrated in the advanced steps of colorectal tumor progression. Little is known, however, about its role in the early phases of the adenoma-carcinoma sequence. Moreover, no data are currently available concerning AURKA involvement in the serrated tumorigenesis. Fluorescence in situ hybridization analysis and immunohistochemistry were used to assess gene copy number and protein expression in 40 colorectal adenomas, 20 cancerized adenomas, and 20 serrated polyps. An increased copy number was found either in adenomatous tissue or in early cancer in the vast majority of cancerized adenomas, but only in 5% of adenomas (P
| Original language | English |
|---|---|
| Pages (from-to) | 411-418 |
| Number of pages | 8 |
| Journal | Human Pathology |
| Volume | 46 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 2015 |
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Keywords
- AURKA gene
- Cancerized adenoma
- Colorectal adenomas
- Serrated polyps
- Tumor progression
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)
Cite this
Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression. / Casorzo, Laura; Dell'Aglio, Carmine; Sarotto, Ivana; Risio, Mauro.
In: Human Pathology, Vol. 46, No. 3, 01.03.2015, p. 411-418.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression
AU - Casorzo, Laura
AU - Dell'Aglio, Carmine
AU - Sarotto, Ivana
AU - Risio, Mauro
PY - 2015/3/1
Y1 - 2015/3/1
N2 - A crucial role for Aurora Kinase A (AURKA) gene has been demonstrated in the advanced steps of colorectal tumor progression. Little is known, however, about its role in the early phases of the adenoma-carcinoma sequence. Moreover, no data are currently available concerning AURKA involvement in the serrated tumorigenesis. Fluorescence in situ hybridization analysis and immunohistochemistry were used to assess gene copy number and protein expression in 40 colorectal adenomas, 20 cancerized adenomas, and 20 serrated polyps. An increased copy number was found either in adenomatous tissue or in early cancer in the vast majority of cancerized adenomas, but only in 5% of adenomas (P
AB - A crucial role for Aurora Kinase A (AURKA) gene has been demonstrated in the advanced steps of colorectal tumor progression. Little is known, however, about its role in the early phases of the adenoma-carcinoma sequence. Moreover, no data are currently available concerning AURKA involvement in the serrated tumorigenesis. Fluorescence in situ hybridization analysis and immunohistochemistry were used to assess gene copy number and protein expression in 40 colorectal adenomas, 20 cancerized adenomas, and 20 serrated polyps. An increased copy number was found either in adenomatous tissue or in early cancer in the vast majority of cancerized adenomas, but only in 5% of adenomas (P
KW - AURKA gene
KW - Cancerized adenoma
KW - Colorectal adenomas
KW - Serrated polyps
KW - Tumor progression
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UR - http://www.scopus.com/inward/citedby.url?scp=84924618432&partnerID=8YFLogxK
U2 - 10.1016/j.humpath.2014.11.016
DO - 10.1016/j.humpath.2014.11.016
M3 - Article
C2 - 25596657
AN - SCOPUS:84924618432
VL - 46
SP - 411
EP - 418
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 3
ER -