Abstract
A crucial role for Aurora Kinase A (AURKA) gene has been demonstrated in the advanced steps of colorectal tumor progression. Little is known, however, about its role in the early phases of the adenoma-carcinoma sequence. Moreover, no data are currently available concerning AURKA involvement in the serrated tumorigenesis. Fluorescence in situ hybridization analysis and immunohistochemistry were used to assess gene copy number and protein expression in 40 colorectal adenomas, 20 cancerized adenomas, and 20 serrated polyps. An increased copy number was found either in adenomatous tissue or in early cancer in the vast majority of cancerized adenomas, but only in 5% of adenomas (P
Original language | English |
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Pages (from-to) | 411-418 |
Number of pages | 8 |
Journal | Human Pathology |
Volume | 46 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 1 2015 |
Keywords
- AURKA gene
- Cancerized adenoma
- Colorectal adenomas
- Serrated polyps
- Tumor progression
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)