Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression

Laura Casorzo; Carmine Dell'Aglio; Ivana Sarotto; Mauro Risio

doi:10.1016/j.humpath.2014.11.016

Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression

Laura Casorzo, Carmine Dell'Aglio, Ivana Sarotto, Mauro Risio

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article

Abstract

A crucial role for Aurora Kinase A (AURKA) gene has been demonstrated in the advanced steps of colorectal tumor progression. Little is known, however, about its role in the early phases of the adenoma-carcinoma sequence. Moreover, no data are currently available concerning AURKA involvement in the serrated tumorigenesis. Fluorescence in situ hybridization analysis and immunohistochemistry were used to assess gene copy number and protein expression in 40 colorectal adenomas, 20 cancerized adenomas, and 20 serrated polyps. An increased copy number was found either in adenomatous tissue or in early cancer in the vast majority of cancerized adenomas, but only in 5% of adenomas (P

Original language	English
Pages (from-to)	411-418
Number of pages	8
Journal	Human Pathology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.humpath.2014.11.016
Publication status	Published - Mar 1 2015

Keywords

AURKA gene
Cancerized adenoma
Colorectal adenomas
Serrated polyps
Tumor progression

ASJC Scopus subject areas

Pathology and Forensic Medicine
Medicine(all)

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Casorzo, L., Dell'Aglio, C., Sarotto, I., & Risio, M. (2015). Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression. Human Pathology, 46(3), 411-418. https://doi.org/10.1016/j.humpath.2014.11.016

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abstract = "A crucial role for Aurora Kinase A (AURKA) gene has been demonstrated in the advanced steps of colorectal tumor progression. Little is known, however, about its role in the early phases of the adenoma-carcinoma sequence. Moreover, no data are currently available concerning AURKA involvement in the serrated tumorigenesis. Fluorescence in situ hybridization analysis and immunohistochemistry were used to assess gene copy number and protein expression in 40 colorectal adenomas, 20 cancerized adenomas, and 20 serrated polyps. An increased copy number was found either in adenomatous tissue or in early cancer in the vast majority of cancerized adenomas, but only in 5% of adenomas (P ",

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