Autism, macrocrania and epilepsy: How are they linked?

Antonia Parmeggiani, Annio Posar, Paola Giovanardi-Rossi, Frederick Andermann, Benjamin Zifkin

Research output: Contribution to journalArticlepeer-review


To evaluate the possible association of autistic disorder (AD), macrocrania and epilepsy, we performed a retrospective study comparing epileptic and non-epileptic AD patients with macrocrania, and AD patients with macrocrania to age- and sex-matched AD controls without macrocrania. We found macrocrania in 17.3% of 121 patients with AD. Epilepsy was not significantly more frequent in AD patients with macrocrania than in those without macrocrania. There were no significant differences in the other clinical characteristics studied except for epileptiform EEG abnormalities which were more often found in AD patients with epilepsy. AD with macrocrania and epilepsy is not a syndrome but may be a marker for a group of subjects with AD. A role for familial macrocrania needs further assessment.

Original languageEnglish
Pages (from-to)296-299
Number of pages4
JournalBrain and Development
Issue number5
Publication statusPublished - 2002


  • Autistic disorder
  • Epilepsy
  • Macrocephaly
  • Macrocrania
  • Mental retardation
  • Pervasive developmental disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology


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