Autism spectrum disorder and mirna: An overview of experimental models

Giovanni Schepici, Eugenio Cavalli, Placido Bramanti, Emanuela Mazzon

Research output: Contribution to journalReview articlepeer-review


Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder characterized by deficits in social interactions, communication, language, and in a limited repertoire of activities and interests. The etiology of ASD is very complex. Genetic, epigenetic, and environmental factors contribute to the onset of ASD. Researchers have shown that microRNAs (miRNAs) could be one of the possible causes associated with ASD. miRNAs are small noncoding mRNAs that regulate gene expression, and they are often linked to biological processes and implicated in neurodevelopment. This review aims to provide an overview of the animal models and the role of the different miRNAs involved in ASD. Therefore, the use of animal models that reproduce the ASD and the identification of miRNAs could be a useful predictive tool to study this disorder.

Original languageEnglish
Article number265
JournalBrain Sciences
Issue number10
Publication statusPublished - Oct 2019


  • Autism spectrum disorder
  • Experimental models
  • MiRNA

ASJC Scopus subject areas

  • Neuroscience(all)


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