Autoantibodies against Leydig cells in patients after spermatic cord torsion

R. Zanchetta, I. Mastrogiacomo, P. Graziotti, C. Foresta, C. Betterle

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Abstract

This study is aimed at searching for the presence of circulating antibodies against frozen sections of human testis, ovary and trophoblast in patients who had spermatic cord torsion. Sixty-eight samples were studied. Nine patients (13.2%) were positive for organ specific anti-testis autoantibodies. Six patients were positive for antibodies against Leydig cells; five were positive only with the indirect immunofluorescence technique of complement fixing (ITT/CF), the sixth patient was positive only with the indirect immunofluorescence technique (ITT). The other three patients were positive for antibodies against germ line cells; two patients were positive with both techniques, the third was positive only with indirect immunofluorescence technique. Eight of these patients were negative for antibodies against adrenal cortex while only one case was positive with indirect immunofluorescence technique both on adrenal cortex and Leydig cells. Human lyophilized testis absorbed the reactive antibodies against Leydig cells and germ line cells, while adrenal cortex and lyophilized testosterone were ineffective. This study shows the identification of a specific antibody against Leydig cells and germ line cells in patients after spermatic cord torsion.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalClinical and Experimental Immunology
Volume55
Issue number1
Publication statusPublished - 1984

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Spermatic Cord Torsion
Leydig Cells
Autoantibodies
Indirect Fluorescent Antibody Technique
Antibodies
Adrenal Cortex
Germ Cells
Testis
Cell Line
Trophoblasts
Frozen Sections
Testosterone
Ovary

ASJC Scopus subject areas

  • Immunology

Cite this

Zanchetta, R., Mastrogiacomo, I., Graziotti, P., Foresta, C., & Betterle, C. (1984). Autoantibodies against Leydig cells in patients after spermatic cord torsion. Clinical and Experimental Immunology, 55(1), 49-57.

Autoantibodies against Leydig cells in patients after spermatic cord torsion. / Zanchetta, R.; Mastrogiacomo, I.; Graziotti, P.; Foresta, C.; Betterle, C.

In: Clinical and Experimental Immunology, Vol. 55, No. 1, 1984, p. 49-57.

Research output: Contribution to journalArticle

Zanchetta, R, Mastrogiacomo, I, Graziotti, P, Foresta, C & Betterle, C 1984, 'Autoantibodies against Leydig cells in patients after spermatic cord torsion', Clinical and Experimental Immunology, vol. 55, no. 1, pp. 49-57.
Zanchetta R, Mastrogiacomo I, Graziotti P, Foresta C, Betterle C. Autoantibodies against Leydig cells in patients after spermatic cord torsion. Clinical and Experimental Immunology. 1984;55(1):49-57.
Zanchetta, R. ; Mastrogiacomo, I. ; Graziotti, P. ; Foresta, C. ; Betterle, C. / Autoantibodies against Leydig cells in patients after spermatic cord torsion. In: Clinical and Experimental Immunology. 1984 ; Vol. 55, No. 1. pp. 49-57.
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