AUTOANTICORPS CONTRE LES LIPOPROTEINES DE BASSE DENSITE OXYDEES CHEZ DES PATIENTS CORONARIENS

Translated title of the contribution: Autoantibodies against oxidised low-density lipoproteins in patients with coronary atherosclerosis

E. Maggi, G. Perani, F. Falaschi, A. Frattoni, A. Martignoni, G. Finardi, P. L. Stefano, F. Simeone, G. Paolini, E. DeVecchi, A. Grossi, G. Bellomo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: Evidence has been obtained indicating that oxidation of low-density lipoproteins (LDL) plays a relevant role in the pathogenesis of atherosclerosis and it has been proposed that, due to the antigenic properties of oxidized LDL, the anti-oxLDL antibody titre could represent a useful index of in vivo LDL oxidation. Methods: Sixty-nine control subjects and 64 patients scheduled for selective coronary revascularization were investigated before surgery. Results: The coronary disease patients had a higher level of total plasma cholesterol, LDL cholesterol and triglycerides, and a lower level of HDL cholesterol. Plasma anti-oxLDL antibody titre was measured as the ratio of antibody binding to CuSO4-oxidised LDL versus native LDL. The antibody ratio was higher in coronary patients as compared with control subjects (1.56 ± 0.5 vs 1.0 ± 0.3, p <0.01). A ratio higher than 1.34 (mean of controls ± one standard deviation) was present in 60% of the coronary patients. Subclass analysis indicated that the presence of diabetes mellitus and hypercholesterolaemia (but not of hypertension, generalized arteriosclerosis, myocardial infarction and cigarette smoking) increased the anti-oxLDL antibody ratio to 1.72 ± 0.4 and 1.68 ± 0.3 respectively. Conclusion: The results obtained indicate that a) a high titre of anti-oxLDL antibodies is present in plasma of patients with coronary atherosclerosis, b) in these patients LDL oxidation takes place in vivo and probably plays a critical role in the development and progression of atherosclerosis.

Original languageFrench
Pages (from-to)1158-1162
Number of pages5
JournalPresse medicale (Paris, France : 1983)
Volume23
Issue number25
Publication statusPublished - 1994

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Autoantibodies
Coronary Artery Disease
LDL Lipoproteins
Anti-Idiotypic Antibodies
Atherosclerosis
Lipoprotein(a)
Antibodies
Arteriosclerosis
Hypercholesterolemia
LDL Cholesterol
HDL Cholesterol
Coronary Disease
oxidized low density lipoprotein
Diabetes Mellitus
Smoking
Myocardial Infarction
Cholesterol
Hypertension

ASJC Scopus subject areas

  • Medicine(all)

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AUTOANTICORPS CONTRE LES LIPOPROTEINES DE BASSE DENSITE OXYDEES CHEZ DES PATIENTS CORONARIENS. / Maggi, E.; Perani, G.; Falaschi, F.; Frattoni, A.; Martignoni, A.; Finardi, G.; Stefano, P. L.; Simeone, F.; Paolini, G.; DeVecchi, E.; Grossi, A.; Bellomo, G.

In: Presse medicale (Paris, France : 1983), Vol. 23, No. 25, 1994, p. 1158-1162.

Research output: Contribution to journalArticle

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abstract = "Objectives: Evidence has been obtained indicating that oxidation of low-density lipoproteins (LDL) plays a relevant role in the pathogenesis of atherosclerosis and it has been proposed that, due to the antigenic properties of oxidized LDL, the anti-oxLDL antibody titre could represent a useful index of in vivo LDL oxidation. Methods: Sixty-nine control subjects and 64 patients scheduled for selective coronary revascularization were investigated before surgery. Results: The coronary disease patients had a higher level of total plasma cholesterol, LDL cholesterol and triglycerides, and a lower level of HDL cholesterol. Plasma anti-oxLDL antibody titre was measured as the ratio of antibody binding to CuSO4-oxidised LDL versus native LDL. The antibody ratio was higher in coronary patients as compared with control subjects (1.56 ± 0.5 vs 1.0 ± 0.3, p <0.01). A ratio higher than 1.34 (mean of controls ± one standard deviation) was present in 60{\%} of the coronary patients. Subclass analysis indicated that the presence of diabetes mellitus and hypercholesterolaemia (but not of hypertension, generalized arteriosclerosis, myocardial infarction and cigarette smoking) increased the anti-oxLDL antibody ratio to 1.72 ± 0.4 and 1.68 ± 0.3 respectively. Conclusion: The results obtained indicate that a) a high titre of anti-oxLDL antibodies is present in plasma of patients with coronary atherosclerosis, b) in these patients LDL oxidation takes place in vivo and probably plays a critical role in the development and progression of atherosclerosis.",
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AU - Perani, G.

AU - Falaschi, F.

AU - Frattoni, A.

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AU - Stefano, P. L.

AU - Simeone, F.

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AU - DeVecchi, E.

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AU - Bellomo, G.

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