Autoantibodies against the endothelial receptor of protein C are associated with acute myocardial infarction in young women

Ramón Montes, V. Hurtado, Á Alonso, L. Foco, P. Zonzin, P. M. Mannucci, J. Hermida

Research output: Contribution to journalArticle

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Abstract

Background: Acute myocardial infarction (AMI) is rare among young women. The search for unknown risk factors is warranted. Endothelial protein C receptor (EPCR) is largely present at the endothelial surface of large arteries. No studies about association of anti-EPCR autoantibodies (anti-EPCR) with AMI are available. Methods: Plasma IgA, IgM and IgG anti-EPCR levels were measured by enzyme-linked immunosorbent assay in 165 women younger than 45 years who survived a first AMI and 165 healthy women, matched by age and geographical origin. Results: Using the 90th percentile of IgA anti-EPCR in the control group, IgA anti-EPCR were independently associated with AMI after adjustment for cardiovascular risk factors (OR 5.1; 95% CI 1.7-15.6; P = 0.004). The risk apparently conferred by IgA anti-EPCR increased dose-dependently (P for trend = 0.0002). IgM anti-EPCR were less consistently associated with AMI: a significant increase in the risk was found when women above the 90th percentile were compared with those in the lowest quartile (OR 3.6; 95% CI 1.2-11.5; P = 0.03). IgG anti-EPCR were similar in patients and controls. A total of 145 patients underwent coronary arteriography. IgA or IgM anti-EPCR were not different among patients with different degrees of atherosclerotic lesion (ANOVA, P = 0.77 and 0.24, respectively). Conclusions: High levels of IgA and, to a lesser extent, IgM anti-EPCR, are associated with AMI in young women.

Original languageEnglish
Pages (from-to)1454-1458
Number of pages5
JournalJournal of Thrombosis and Haemostasis
Volume3
Issue number7
DOIs
Publication statusPublished - 2005

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Protein C
Autoantibodies
Myocardial Infarction
Immunoglobulin A
Analysis of Variance
Angiography
Arteries
Enzyme-Linked Immunosorbent Assay
anti-IgA
Control Groups
anti-IgM

Keywords

  • Antibodies
  • Endothelium
  • Myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Autoantibodies against the endothelial receptor of protein C are associated with acute myocardial infarction in young women. / Montes, Ramón; Hurtado, V.; Alonso, Á; Foco, L.; Zonzin, P.; Mannucci, P. M.; Hermida, J.

In: Journal of Thrombosis and Haemostasis, Vol. 3, No. 7, 2005, p. 1454-1458.

Research output: Contribution to journalArticle

Montes, Ramón ; Hurtado, V. ; Alonso, Á ; Foco, L. ; Zonzin, P. ; Mannucci, P. M. ; Hermida, J. / Autoantibodies against the endothelial receptor of protein C are associated with acute myocardial infarction in young women. In: Journal of Thrombosis and Haemostasis. 2005 ; Vol. 3, No. 7. pp. 1454-1458.
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abstract = "Background: Acute myocardial infarction (AMI) is rare among young women. The search for unknown risk factors is warranted. Endothelial protein C receptor (EPCR) is largely present at the endothelial surface of large arteries. No studies about association of anti-EPCR autoantibodies (anti-EPCR) with AMI are available. Methods: Plasma IgA, IgM and IgG anti-EPCR levels were measured by enzyme-linked immunosorbent assay in 165 women younger than 45 years who survived a first AMI and 165 healthy women, matched by age and geographical origin. Results: Using the 90th percentile of IgA anti-EPCR in the control group, IgA anti-EPCR were independently associated with AMI after adjustment for cardiovascular risk factors (OR 5.1; 95{\%} CI 1.7-15.6; P = 0.004). The risk apparently conferred by IgA anti-EPCR increased dose-dependently (P for trend = 0.0002). IgM anti-EPCR were less consistently associated with AMI: a significant increase in the risk was found when women above the 90th percentile were compared with those in the lowest quartile (OR 3.6; 95{\%} CI 1.2-11.5; P = 0.03). IgG anti-EPCR were similar in patients and controls. A total of 145 patients underwent coronary arteriography. IgA or IgM anti-EPCR were not different among patients with different degrees of atherosclerotic lesion (ANOVA, P = 0.77 and 0.24, respectively). Conclusions: High levels of IgA and, to a lesser extent, IgM anti-EPCR, are associated with AMI in young women.",
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AU - Montes, Ramón

AU - Hurtado, V.

AU - Alonso, Á

AU - Foco, L.

AU - Zonzin, P.

AU - Mannucci, P. M.

AU - Hermida, J.

PY - 2005

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N2 - Background: Acute myocardial infarction (AMI) is rare among young women. The search for unknown risk factors is warranted. Endothelial protein C receptor (EPCR) is largely present at the endothelial surface of large arteries. No studies about association of anti-EPCR autoantibodies (anti-EPCR) with AMI are available. Methods: Plasma IgA, IgM and IgG anti-EPCR levels were measured by enzyme-linked immunosorbent assay in 165 women younger than 45 years who survived a first AMI and 165 healthy women, matched by age and geographical origin. Results: Using the 90th percentile of IgA anti-EPCR in the control group, IgA anti-EPCR were independently associated with AMI after adjustment for cardiovascular risk factors (OR 5.1; 95% CI 1.7-15.6; P = 0.004). The risk apparently conferred by IgA anti-EPCR increased dose-dependently (P for trend = 0.0002). IgM anti-EPCR were less consistently associated with AMI: a significant increase in the risk was found when women above the 90th percentile were compared with those in the lowest quartile (OR 3.6; 95% CI 1.2-11.5; P = 0.03). IgG anti-EPCR were similar in patients and controls. A total of 145 patients underwent coronary arteriography. IgA or IgM anti-EPCR were not different among patients with different degrees of atherosclerotic lesion (ANOVA, P = 0.77 and 0.24, respectively). Conclusions: High levels of IgA and, to a lesser extent, IgM anti-EPCR, are associated with AMI in young women.

AB - Background: Acute myocardial infarction (AMI) is rare among young women. The search for unknown risk factors is warranted. Endothelial protein C receptor (EPCR) is largely present at the endothelial surface of large arteries. No studies about association of anti-EPCR autoantibodies (anti-EPCR) with AMI are available. Methods: Plasma IgA, IgM and IgG anti-EPCR levels were measured by enzyme-linked immunosorbent assay in 165 women younger than 45 years who survived a first AMI and 165 healthy women, matched by age and geographical origin. Results: Using the 90th percentile of IgA anti-EPCR in the control group, IgA anti-EPCR were independently associated with AMI after adjustment for cardiovascular risk factors (OR 5.1; 95% CI 1.7-15.6; P = 0.004). The risk apparently conferred by IgA anti-EPCR increased dose-dependently (P for trend = 0.0002). IgM anti-EPCR were less consistently associated with AMI: a significant increase in the risk was found when women above the 90th percentile were compared with those in the lowest quartile (OR 3.6; 95% CI 1.2-11.5; P = 0.03). IgG anti-EPCR were similar in patients and controls. A total of 145 patients underwent coronary arteriography. IgA or IgM anti-EPCR were not different among patients with different degrees of atherosclerotic lesion (ANOVA, P = 0.77 and 0.24, respectively). Conclusions: High levels of IgA and, to a lesser extent, IgM anti-EPCR, are associated with AMI in young women.

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