Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy

R. Nemni, S. Braghi, M. G. Natali-Sora, V. Lampasona, E. Bonifacio, G. Comi, N. Canal

Research output: Contribution to journalArticle

Abstract

We report the presence of serum autoantibodies directed against glutamic acid decarboxylase in a patient with epilepsy and palatal myoclonus not associated with brain lesions. Glutamic acid decarboxylase antibody reactivity was dependent on the presence of carboxy-terminal amino acids, similar to that reported in patients with stiff-man syndrome. Marked reduction in the frequency of epileptic attacks and improvement in palatal myoclonus occurred when benzodiazepine was administered and phenytoin was gradually tapered. Testing for antiglutamic acid decarboxylase antibodies may be indicated in patients with palatal myoclonus and with convulsive disorders refractory to therapy.

Original languageEnglish
Pages (from-to)665-667
Number of pages3
JournalAnnals of Neurology
Volume36
Issue number4
DOIs
Publication statusPublished - Oct 1994

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy'. Together they form a unique fingerprint.

  • Cite this