Autoantibodies to heterogeneous nuclear ribonucleoproteins

Research output: Contribution to journalArticlepeer-review

Abstract

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are among the most abundant proteins in the eukaryotic cell nucleus and play a direct role in several aspects of the RNA life including splicing, export of the mature RNAs and translation. To date, ∼ 30 proteins have been identified. A growing body of evidence points to hnRNPs as an important target of the autoimmune response in rheumatic diseases. Autoantibodies to A and B proteins of the hnRNP complex have been detected in late 1980s in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). Beyond their role as diagnostic test in clinical practice, these autoantibodies are starting to be regarded as important tools to obtain deeper insight into the pathogenesis of autoimmune rheumatic diseases. Furthermore, new anti-hnRNP antibodies have been recognized in the last ten years extending the spectrum of anti-hnRNP reactivity in different autoimmune disorders.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalAutoimmunity
Volume38
Issue number1
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Autoantibodies
  • Heterogeneous nuclear ribonucleoproteins
  • Mixed connective tissue disease
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Autoantibodies to heterogeneous nuclear ribonucleoproteins'. Together they form a unique fingerprint.

Cite this