TY - JOUR
T1 - Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy
AU - Notturno, Francesca
AU - Di Febo, Tiziana
AU - Yuki, Nobuhiro
AU - Fernandez Rodriguez, Blanca M.
AU - Corti, Davide
AU - Nobile-Orazio, Eduardo
AU - Carpo, Marinella
AU - De Lauretis, Angelo
AU - Uncini, Antonino
PY - 2014/11/15
Y1 - 2014/11/15
N2 - We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.
AB - We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.
KW - Chronic inflammatory demyelinating neuropathy
KW - Gliomedin
KW - Multifocal motor neuropathy
KW - Neurofascin
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U2 - 10.1016/j.jneuroim.2014.09.001
DO - 10.1016/j.jneuroim.2014.09.001
M3 - Article
C2 - 25283719
AN - SCOPUS:84908546515
VL - 276
SP - 207
EP - 212
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -