Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

Francesca Notturno, Tiziana Di Febo, Nobuhiro Yuki, Blanca M. Fernandez Rodriguez, Davide Corti, Eduardo Nobile-Orazio, Marinella Carpo, Angelo De Lauretis, Antonino Uncini

Research output: Contribution to journalArticle

Abstract

We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalJournal of Neuroimmunology
Volume276
Issue number1-2
DOIs
Publication statusPublished - Nov 15 2014

Fingerprint

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Autoantibodies
Serum
Antibodies
Nerve Block
Neural Conduction
Muscle Weakness
Immunoglobulin M
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Antigens

Keywords

  • Chronic inflammatory demyelinating neuropathy
  • Gliomedin
  • Multifocal motor neuropathy
  • Neurofascin

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology
  • Medicine(all)

Cite this

Notturno, F., Di Febo, T., Yuki, N., Fernandez Rodriguez, B. M., Corti, D., Nobile-Orazio, E., ... Uncini, A. (2014). Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. Journal of Neuroimmunology, 276(1-2), 207-212. https://doi.org/10.1016/j.jneuroim.2014.09.001

Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. / Notturno, Francesca; Di Febo, Tiziana; Yuki, Nobuhiro; Fernandez Rodriguez, Blanca M.; Corti, Davide; Nobile-Orazio, Eduardo; Carpo, Marinella; De Lauretis, Angelo; Uncini, Antonino.

In: Journal of Neuroimmunology, Vol. 276, No. 1-2, 15.11.2014, p. 207-212.

Research output: Contribution to journalArticle

Notturno, F, Di Febo, T, Yuki, N, Fernandez Rodriguez, BM, Corti, D, Nobile-Orazio, E, Carpo, M, De Lauretis, A & Uncini, A 2014, 'Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy', Journal of Neuroimmunology, vol. 276, no. 1-2, pp. 207-212. https://doi.org/10.1016/j.jneuroim.2014.09.001
Notturno, Francesca ; Di Febo, Tiziana ; Yuki, Nobuhiro ; Fernandez Rodriguez, Blanca M. ; Corti, Davide ; Nobile-Orazio, Eduardo ; Carpo, Marinella ; De Lauretis, Angelo ; Uncini, Antonino. / Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. In: Journal of Neuroimmunology. 2014 ; Vol. 276, No. 1-2. pp. 207-212.
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