Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

Francesca Notturno, Tiziana Di Febo, Nobuhiro Yuki, Blanca M. Fernandez Rodriguez, Davide Corti, Eduardo Nobile-Orazio, Marinella Carpo, Angelo De Lauretis, Antonino Uncini

Research output: Contribution to journalArticlepeer-review

Abstract

We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalJournal of Neuroimmunology
Volume276
Issue number1-2
DOIs
Publication statusPublished - Nov 15 2014

Keywords

  • Chronic inflammatory demyelinating neuropathy
  • Gliomedin
  • Multifocal motor neuropathy
  • Neurofascin

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy'. Together they form a unique fingerprint.

Cite this