Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

Francesca Notturno; Tiziana Di Febo; Nobuhiro Yuki; Blanca M. Fernandez Rodriguez; Davide Corti; Eduardo Nobile-Orazio; Marinella Carpo; Angelo De Lauretis; Antonino Uncini

doi:10.1016/j.jneuroim.2014.09.001

Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

Francesca Notturno, Tiziana Di Febo, Nobuhiro Yuki, Blanca M. Fernandez Rodriguez, Davide Corti, Eduardo Nobile-Orazio, Marinella Carpo, Angelo De Lauretis, Antonino Uncini

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.

Original language	English
Pages (from-to)	207-212
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	276
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2014.09.001
Publication status	Published - Nov 15 2014

Keywords

Chronic inflammatory demyelinating neuropathy
Gliomedin
Multifocal motor neuropathy
Neurofascin

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology
Medicine(all)

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10.1016/j.jneuroim.2014.09.001

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title = "Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy",

abstract = "We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.",

keywords = "Chronic inflammatory demyelinating neuropathy, Gliomedin, Multifocal motor neuropathy, Neurofascin",

author = "Francesca Notturno and {Di Febo}, Tiziana and Nobuhiro Yuki and {Fernandez Rodriguez}, {Blanca M.} and Davide Corti and Eduardo Nobile-Orazio and Marinella Carpo and {De Lauretis}, Angelo and Antonino Uncini",

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doi = "10.1016/j.jneuroim.2014.09.001",

language = "English",

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T1 - Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

AU - Notturno, Francesca

AU - Di Febo, Tiziana

AU - Yuki, Nobuhiro

AU - Fernandez Rodriguez, Blanca M.

AU - Corti, Davide

AU - Nobile-Orazio, Eduardo

AU - Carpo, Marinella

AU - De Lauretis, Angelo

AU - Uncini, Antonino

PY - 2014/11/15

Y1 - 2014/11/15

N2 - We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.

AB - We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.

KW - Chronic inflammatory demyelinating neuropathy

KW - Gliomedin

KW - Multifocal motor neuropathy

KW - Neurofascin

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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