Abstract
We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.
| Original language | English |
|---|---|
| Pages (from-to) | 207-212 |
| Number of pages | 6 |
| Journal | Journal of Neuroimmunology |
| Volume | 276 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Nov 15 2014 |
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Keywords
- Chronic inflammatory demyelinating neuropathy
- Gliomedin
- Multifocal motor neuropathy
- Neurofascin
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
- Medicine(all)
Cite this
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. / Notturno, Francesca; Di Febo, Tiziana; Yuki, Nobuhiro; Fernandez Rodriguez, Blanca M.; Corti, Davide; Nobile-Orazio, Eduardo; Carpo, Marinella; De Lauretis, Angelo; Uncini, Antonino.
In: Journal of Neuroimmunology, Vol. 276, No. 1-2, 15.11.2014, p. 207-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy
AU - Notturno, Francesca
AU - Di Febo, Tiziana
AU - Yuki, Nobuhiro
AU - Fernandez Rodriguez, Blanca M.
AU - Corti, Davide
AU - Nobile-Orazio, Eduardo
AU - Carpo, Marinella
AU - De Lauretis, Angelo
AU - Uncini, Antonino
PY - 2014/11/15
Y1 - 2014/11/15
N2 - We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.
AB - We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.
KW - Chronic inflammatory demyelinating neuropathy
KW - Gliomedin
KW - Multifocal motor neuropathy
KW - Neurofascin
UR - http://www.scopus.com/inward/record.url?scp=84908546515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908546515&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2014.09.001
DO - 10.1016/j.jneuroim.2014.09.001
M3 - Article
C2 - 25283719
AN - SCOPUS:84908546515
VL - 276
SP - 207
EP - 212
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -