Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk

P. Achenbach, V. Lampasona, U. Landherr, K. Koczwara, S. Krause, H. Grallert, C. Winkler, M. Pflüger, T. Illig, E. Bonifacio, A. G. Ziegler

Research output: Contribution to journalArticle

Abstract

Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH2-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.

Original languageEnglish
Pages (from-to)1881-1888
Number of pages8
JournalDiabetologia
Volume52
Issue number9
DOIs
Publication statusPublished - Sep 2009

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Achenbach, P., Lampasona, V., Landherr, U., Koczwara, K., Krause, S., Grallert, H., Winkler, C., Pflüger, M., Illig, T., Bonifacio, E., & Ziegler, A. G. (2009). Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia, 52(9), 1881-1888. https://doi.org/10.1007/s00125-009-1438-0