Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk

P. Achenbach; V. Lampasona; U. Landherr; K. Koczwara; S. Krause; H. Grallert; C. Winkler; M. Pflüger; T. Illig; E. Bonifacio; A. G. Ziegler

doi:10.1007/s00125-009-1438-0

Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk

P. Achenbach, V. Lampasona, U. Landherr, K. Koczwara, S. Krause, H. Grallert, C. Winkler, M. Pflüger, T. Illig, E. Bonifacio, A. G. Ziegler

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH₂-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.

Original language	English
Pages (from-to)	1881-1888
Number of pages	8
Journal	Diabetologia
Volume	52
Issue number	9
DOIs	https://doi.org/10.1007/s00125-009-1438-0
Publication status	Published - Sep 2009

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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Achenbach, P., Lampasona, V., Landherr, U., Koczwara, K., Krause, S., Grallert, H., Winkler, C., Pflüger, M., Illig, T., Bonifacio, E., & Ziegler, A. G. (2009). Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia, 52(9), 1881-1888. https://doi.org/10.1007/s00125-009-1438-0

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abstract = "Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH2-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.",

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AU - Achenbach, P.

AU - Lampasona, V.

AU - Landherr, U.

AU - Koczwara, K.

AU - Krause, S.

AU - Grallert, H.

AU - Winkler, C.

AU - Pflüger, M.

AU - Illig, T.

AU - Bonifacio, E.

AU - Ziegler, A. G.

PY - 2009/9

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N2 - Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH2-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.

AB - Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH2-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.

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