Autocrine growth of leukemic cells

Claude Jasmin, Vassilis Georgoulias, Florence Smadja-Joffe, Claude Boucheix, Caroline Le Bousse-Kerdiles, Michèle Allouche, Christian Cibert, Bruno Azzarone

Research output: Contribution to journalArticlepeer-review


Autocrine growth is a process whereby a cell both secretes and responds to a growth factor. This paper describes the stepwise malignant progression of leukemic cells which has been demonstrated in many experimental models of autocrine leukemic growth. In contrast, autocrine growth has not been proven as a major physiopathological mechanism for the growth of leukemic cells in vivo in human myeloid and lymphocytic leukemias. Growth-factor independency of human leukemic cell lines may be due to clonal selection.

Original languageEnglish
Pages (from-to)689-693
Number of pages5
JournalLeukemia Research
Issue number8
Publication statusPublished - 1990


  • Autocrine growth
  • autocrine loop
  • growth-factor
  • leukemia
  • paracrine growth
  • receptor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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