Autofluorescence in adult-onset foveomacular vitelliform dystrophy

Maurizio Battaglia Parodi, Pierluigi Iacono, Marcella Pedio, Alfredo Pece, Vincenzo Isola, Alessandro Fachin, Marinella Pinto, Giuseppe Ravalico

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

PURPOSE: To describe fundus autofluorescence (FAF) characteristics of adult-onset foveomacular vitelliform dystrophy (AOFVD) and to perform a comparative evaluation of FAF patterns and functional response. METHODS: Fifteen patients with AOFVD and 10 healthy volunteers underwent complete ophthalmic examination, including visual acuity determination (Early Treatment Diabetic Retinopathy Study charts), blue-light autofluorescence (BL-AF) analysis, near-infrared autofluorescence (NIR-AF) analysis, and microperimetry. RESULTS: Three different patterns of BL-AF (normal, focal, and patchy) and two of NIR-AF (focal and patchy) were identified in AOFVD. Abnormal BL-AF and NIR-AF patterns were detectable in 86% and 100% of cases, respectively. Patchy BL-AF and NIR-AF patterns are associated with the worst functional outcomes. CONCLUSIONS: AOFVD can be associated with different FAF patterns. A functional correlate with visual acuity and retinal sensitivity, measured by means of microperimetry, can be found.

Original languageEnglish
Pages (from-to)801-807
Number of pages7
JournalRetina
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2008

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Vitelliform Macular Dystrophy
Light
Visual Acuity
Diabetic Retinopathy
Healthy Volunteers

Keywords

  • Adult-onset foveomacular vitelliform dystrophy
  • Fundus autofluorescence
  • Microperimetry

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Parodi, M. B., Iacono, P., Pedio, M., Pece, A., Isola, V., Fachin, A., ... Ravalico, G. (2008). Autofluorescence in adult-onset foveomacular vitelliform dystrophy. Retina, 28(6), 801-807. https://doi.org/10.1097/IAE.0b013e31816f859d

Autofluorescence in adult-onset foveomacular vitelliform dystrophy. / Parodi, Maurizio Battaglia; Iacono, Pierluigi; Pedio, Marcella; Pece, Alfredo; Isola, Vincenzo; Fachin, Alessandro; Pinto, Marinella; Ravalico, Giuseppe.

In: Retina, Vol. 28, No. 6, 06.2008, p. 801-807.

Research output: Contribution to journalArticle

Parodi, MB, Iacono, P, Pedio, M, Pece, A, Isola, V, Fachin, A, Pinto, M & Ravalico, G 2008, 'Autofluorescence in adult-onset foveomacular vitelliform dystrophy', Retina, vol. 28, no. 6, pp. 801-807. https://doi.org/10.1097/IAE.0b013e31816f859d
Parodi, Maurizio Battaglia ; Iacono, Pierluigi ; Pedio, Marcella ; Pece, Alfredo ; Isola, Vincenzo ; Fachin, Alessandro ; Pinto, Marinella ; Ravalico, Giuseppe. / Autofluorescence in adult-onset foveomacular vitelliform dystrophy. In: Retina. 2008 ; Vol. 28, No. 6. pp. 801-807.
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AB - PURPOSE: To describe fundus autofluorescence (FAF) characteristics of adult-onset foveomacular vitelliform dystrophy (AOFVD) and to perform a comparative evaluation of FAF patterns and functional response. METHODS: Fifteen patients with AOFVD and 10 healthy volunteers underwent complete ophthalmic examination, including visual acuity determination (Early Treatment Diabetic Retinopathy Study charts), blue-light autofluorescence (BL-AF) analysis, near-infrared autofluorescence (NIR-AF) analysis, and microperimetry. RESULTS: Three different patterns of BL-AF (normal, focal, and patchy) and two of NIR-AF (focal and patchy) were identified in AOFVD. Abnormal BL-AF and NIR-AF patterns were detectable in 86% and 100% of cases, respectively. Patchy BL-AF and NIR-AF patterns are associated with the worst functional outcomes. CONCLUSIONS: AOFVD can be associated with different FAF patterns. A functional correlate with visual acuity and retinal sensitivity, measured by means of microperimetry, can be found.

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