Autofluorescence in adult-onset foveomacular vitelliform dystrophy

Maurizio Battaglia Parodi, Pierluigi Iacono, Marcella Pedio, Alfredo Pece, Vincenzo Isola, Alessandro Fachin, Marinella Pinto, Giuseppe Ravalico

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To describe fundus autofluorescence (FAF) characteristics of adult-onset foveomacular vitelliform dystrophy (AOFVD) and to perform a comparative evaluation of FAF patterns and functional response. METHODS: Fifteen patients with AOFVD and 10 healthy volunteers underwent complete ophthalmic examination, including visual acuity determination (Early Treatment Diabetic Retinopathy Study charts), blue-light autofluorescence (BL-AF) analysis, near-infrared autofluorescence (NIR-AF) analysis, and microperimetry. RESULTS: Three different patterns of BL-AF (normal, focal, and patchy) and two of NIR-AF (focal and patchy) were identified in AOFVD. Abnormal BL-AF and NIR-AF patterns were detectable in 86% and 100% of cases, respectively. Patchy BL-AF and NIR-AF patterns are associated with the worst functional outcomes. CONCLUSIONS: AOFVD can be associated with different FAF patterns. A functional correlate with visual acuity and retinal sensitivity, measured by means of microperimetry, can be found.

Original languageEnglish
Pages (from-to)801-807
Number of pages7
JournalRetina
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Adult-onset foveomacular vitelliform dystrophy
  • Fundus autofluorescence
  • Microperimetry

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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