Autografteng followed by interferon-alpha increase overall survival in CML patients

Maria T. Corsetti, Eugenio Damasio, Edoardo Rossi, Mauro Spriano, Marco Risso, Germana Beltrami, Marino Clavio, Marco Gobbi, Enrica Lerma, Marina Cavalière, Angelo M. Carella

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Abstract

Interferon-alpha(IFN-α)is the golden standard therapy for CML patients who do not have an HLA-identical donor. Since longer survival was demonstrated for cytogenetic remitter patients, we have carried out a retrospective analysis in Genoa on 137 patients with CML, in the attempt to verify if IFN-α given soon after ASCT could determine a better survival than IFN-α given alone. From January 1985 to August 1999, 137 pts in CP/ CML pretreated with hydroxyurea alone entered in our Department. IFN-a cohort included patients diagnosed between January 1985 and August 1999; ASCT cohort included patients diagnosed between January 1991 to August 1999. No significant difference was found for Sokal index between the two cohort of patiets. The accrual of patients in the treatment arms is due to different therapeutic approach to the disease by the institutions partecipating to such analysis. Out of 137, 28 (20%)pts were not évaluable for our analysis. Fiftytwo(38%)pts received IFN-α and 57(42%) pts were mobilized with chemotherapy and G-CSF to collect Ph-negative cells. In 43 pts out of the 57 mobilized, ASCT followed by IFN-a was given. In IFN-a arm the median dose of IFN-a was 35MU/week.In the ASCT arm, 31 pts received a Ph-negative graft, 9 pts had

Original languageEnglish
JournalBlood
Volume96
Issue number11 PART I
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Hematology

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    Corsetti, M. T., Damasio, E., Rossi, E., Spriano, M., Risso, M., Beltrami, G., Clavio, M., Gobbi, M., Lerma, E., Cavalière, M., & Carella, A. M. (2000). Autografteng followed by interferon-alpha increase overall survival in CML patients. Blood, 96(11 PART I).