Abstract
In the 1970s, when autografting was started, it was hard to imagine that this procedure would have an application in hematological malignancies. Autografting in patients with CML has been difficult to pursue because their bone marrow is often contaminated by Philadelphia-chromosome positive cells. In recent years, renewed interest has come from this procedure and various in vivo or in vitro techniques of manipulation of Ph-positive cells, such as collection of blood progenitor cells in the early phase of recovery after intensive conventional chemotherapy in untreated or pretreated patients, long-term bone marrow culture and chemical purging of marrow cells. Despite all these interesting trials, we do not have enough data to address the question of whether autografting in CML increases the duration of the chronic phase.
| Original language | English |
|---|---|
| Pages (from-to) | 365-369 |
| Number of pages | 5 |
| Journal | Leukemia |
| Volume | 9 |
| Issue number | 3 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Cancer Research
- Hematology
Cite this
Autografting in chronic myelogenous leukemia : New questions. / Carella, A. M.; Frassoni, F.; Negrin, R. S.
In: Leukemia, Vol. 9, No. 3, 1995, p. 365-369.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autografting in chronic myelogenous leukemia
T2 - New questions
AU - Carella, A. M.
AU - Frassoni, F.
AU - Negrin, R. S.
PY - 1995
Y1 - 1995
N2 - In the 1970s, when autografting was started, it was hard to imagine that this procedure would have an application in hematological malignancies. Autografting in patients with CML has been difficult to pursue because their bone marrow is often contaminated by Philadelphia-chromosome positive cells. In recent years, renewed interest has come from this procedure and various in vivo or in vitro techniques of manipulation of Ph-positive cells, such as collection of blood progenitor cells in the early phase of recovery after intensive conventional chemotherapy in untreated or pretreated patients, long-term bone marrow culture and chemical purging of marrow cells. Despite all these interesting trials, we do not have enough data to address the question of whether autografting in CML increases the duration of the chronic phase.
AB - In the 1970s, when autografting was started, it was hard to imagine that this procedure would have an application in hematological malignancies. Autografting in patients with CML has been difficult to pursue because their bone marrow is often contaminated by Philadelphia-chromosome positive cells. In recent years, renewed interest has come from this procedure and various in vivo or in vitro techniques of manipulation of Ph-positive cells, such as collection of blood progenitor cells in the early phase of recovery after intensive conventional chemotherapy in untreated or pretreated patients, long-term bone marrow culture and chemical purging of marrow cells. Despite all these interesting trials, we do not have enough data to address the question of whether autografting in CML increases the duration of the chronic phase.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028912492&partnerID=8YFLogxK
M3 - Article
C2 - 7885034
AN - SCOPUS:0028912492
VL - 9
SP - 365
EP - 369
JO - Leukemia
JF - Leukemia
SN - 0887-6924
IS - 3
ER -